A randomized double-blind placebo-controlled study of the efficacy of Clinpro XT varnish and Gluma dentin desensitizer on dentin hypersensitivity.

Abstract

PURPOSE:

To evaluate the effect of Clinpro XT Varnish (VXT) paste-liquid, resin-modified glass-ionomer and the resinous dentin desensitizing varnish and Gluma Dentin Desensitizer (Gluma) in treating dentin hypersensitivity (DH).

METHODS:

This short-term (4-week) randomized, double-blind, placebo-controlled, split-mouth study included a total of 119 teeth from 31 individuals which were randomized into three groups: VXT, Gluma, and placebo (warm water). Dentin sensitivity was evaluated by subjects' perception of DH determined by pretreatment tooth sensitivity score (TSS) measured on a 0-10 visual analogue scale (VAS) after tactile (probe) or thermal/evaporative (blast of air) stimuli. TSS was scored at baseline, immediately after treatment (Day 0), after 1 week and after 4 weeks.

RESULTS:

For both stimuli, mean TSS was significantly decreased in the VXT and Gluma groups at all time points (all, P < 0.001) compared with baseline. Regarding comparisons of TSS between treatment groups, the VXT group had significantly lower mean TSS compared with the Gluma group (P< 0.05) and placebo control group (P< 0.05) at all time points after treatment regardless of stimuli. Group Effect, Time Effect, and Group x Time Effect were all significantly different (all, P < 0.001).

• Authors: Yi-Jian Ding, Hua Yao, Guo-Hua Wang, Hang Song
• Journal: American journal of dentistry (Am J Dent) Vol. 27 Issue 2 Pg. 79-83 (Apr 2014) ISSN: 0894-8275 [Print] United States
• PMID: 25000665 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Dentin Desensitizing Agents
• Glass Ionomer Cements
• Methacrylates
• Placebos
• Resin Cements
• gluma desensitizer
• Glutaral

Topics

• Adult
• Air
• Dentin Desensitizing Agents (therapeutic use)
• Dentin Sensitivity (classification, drug therapy)
• Double-Blind Method
• Female
• Follow-Up Studies
• Glass Ionomer Cements (therapeutic use)
• Glutaral (therapeutic use)
• Humans
• Male
• Methacrylates (therapeutic use)
• Middle Aged
• Pain Measurement
• Placebos
• Resin Cements (therapeutic use)
• Tooth Cervix (drug effects)
• Touch
• Treatment Outcome
• Visual Analog Scale