Abstract | PURPOSE: METHODS: Eighteen patients with epiphora after SMG transplantation participated in a double-blind, controlled, crossover study. Patients were treated with topical smear common atropine (CA) and modified atropine (MA) gels (intervals ≥1 day). The control effect of atropine gels was observed for 5 hours. Tear flow was quantified in resting and stimulated (after exercise) states using the Schirmer I test. RESULTS: With the CA gel, tear flow decreased significantly at 10, 30, and 120 minutes. Average epiphora reduction rates (AERRs) were 22.37%, 18.14%, and 13.27%, respectively (P<.05). With the MA gel, tear flow decreased significantly from 5 minutes to 5 hours; AERRs increased from 24.06% to 42.67% (P<.05); Maximum efficacy was maintained from 15 minutes to 3 hours (P<.01); Tear flow gradually increased from 4 to 5 hours but was still lower than that before atropine use (P<.05). According to results of the Schirmer I test and AERRs, the control efficacy of the MA gel was significantly better than that of the CA gel (P<.05). CONCLUSIONS:
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Authors | Jian-Rui Cai, Xiao-Feng Shan, Zhi-Gang Cai, Xuan Zhang, Guang-Yan Yu |
Journal | The ocular surface
(Ocul Surf)
Vol. 12
Issue 3
Pg. 221-6
(Jul 2014)
ISSN: 1937-5913 [Electronic] United States |
PMID | 24999104
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Elsevier Inc. All rights reserved. |
Chemical References |
- Gels
- Parasympatholytics
- Atropine
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Topics |
- Administration, Topical
- Adult
- Aged
- Atropine
(administration & dosage)
- Cross-Over Studies
- Double-Blind Method
- Female
- Follow-Up Studies
- Gels
- Humans
- Keratoconjunctivitis Sicca
(surgery)
- Lacrimal Apparatus Diseases
(drug therapy, etiology)
- Male
- Middle Aged
- Parasympatholytics
(administration & dosage)
- Submandibular Gland
(drug effects, transplantation)
- Time Factors
- Transplantation, Autologous
(adverse effects)
- Treatment Outcome
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