Glutathione S-transferase M1 null genotype and hepatocellular carcinoma susceptibility in China and India: evidence from an updated meta-analysis.

Abstract

BACKGROUND:

Glutathione S-transferase M1 (GSTM1) have been reported to be associated with hepatocellular carcinoma. However, the effect of the GSTM1 null genotype was divergent in the literature and we therefore performed the present meta-analysis to explore the relationship in detail.

MATERIALS AND METHODS:

Reported studies were searched from 1990 to March 1, 2014 in PubMed and Wanfang Med Online. The total odds oatio (OR) and 95% CI were calculated and analyzed by Review Manager 5.1 and STATE 12.

RESULTS:

Total OR was calculated from 26 articles with 3,769 cases and 5,517 controls and the association proved significant (OR [95%CI]=1.50 [1.25, 1.80], P<0.05) in the Chinese population. However, there was no significant association between hepatocellular carcinoma risk among subjects carrying the GSTM1 null genotype (OR [95%CI]=1.20 [0.88-1.64], P=0.24) in subgroups of publication in English and in Indian populations (OR [95%CI]=1.80 [0.80- 4.20], P=0.15).

CONCLUSIONS:

The GSTM1 deletion polymorphism might not have a significant effect on the susceptibility of hepatocellular carcinoma overall.

• Authors: Hong-Zhou Liu, Jie Peng, Chun-Yan Peng, Ming Yan, Fang Zheng
• Journal: Asian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 15 Issue 12 Pg. 4851-6 ( 2014) ISSN: 2476-762X [Electronic] Thailand
• PMID: 24998552 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)

Chemical References

• Glutathione Transferase
• glutathione S-transferase M1

Topics

• Carcinoma, Hepatocellular (genetics)
• Case-Control Studies
• China
• Genetic Predisposition to Disease
• Glutathione Transferase (genetics)
• Humans
• India
• Liver Neoplasms (genetics)
• Polymorphism, Genetic (genetics)
• Prognosis