Associations between lipid profiles and MACE in hemodialysis patients with percutaneous coronary intervention: from the FU-Registry.

Abstract

BACKGROUND:

It is well known that percutaneous coronary intervention (PCI) in hemodialysis (HD) patients is associated with higher rates of in-stent restenosis and major adverse cardiovascular events (MACE) compared to that in non-HD patients, even if the target value in cholesterol management is achieved.

METHODS:

To evaluate the factors that are associated with MACE in HD patients, we selected 142 HD patients (164 lesions) without acute coronary syndrome (ACS) from 2148 patients (2568 lesions) who underwent PCI in our database of the FU-Registry [UMIN000005679, Fukuoka University Hospital EC/IRB:10-1-08(09-105)], and compared 52 patients (53 lesions) with MACE [MACE(+)] to 90 patients (111 lesions) without MACE [MACE(-)].

RESULTS:

Total cholesterol (TC: 150±30mg/dL vs 166±39mg/dL, p<0.05) and high-density lipoprotein cholesterol (HDL-C: 40.1±14.7mg/dL vs 47.8±13.5mg/dL, p<0.01) levels were significantly lower in the MACE(+) group at follow-up. No significant differences were observed in other parameters, including triglyceride, low-density lipoprotein cholesterol (LDL-C; LDL-C/HDL-C ratio, and % changes in HDL-C, non-HDL-C, LDL-C), and hemoglobin A1c (US National Glycohemoglobin Standardization Program) between before and after PCI. TC, LDL-C, and non-HDL-C at the time of PCI and TC, and HDL-C at the 9-month follow-up were negatively correlated with MACE, while body mass index (BMI) [odds ratio (OR): 0.81; 95% confidence interval (CI): 0.68-0.95)], prior coronary artery bypass graft (CABG) (OR: 3.89; 95%CI: 1.29-12.6), and insulin use (OR: 3.17; 95%CI: 1.23-8.55) were strongly correlated with MACE in a multivariate analysis.

CONCLUSION:

BMI, CABG, and insulin use, but not LDL-C, are independent predictors of MACE in HD patients, suggesting that the application of lipid management for non-HD patients to HD patients at the time of PCI may not necessarily be beneficial for medium-term clinical outcomes.

• Authors: Itsuki Nagata, Amane Ike, Hiroaki Nishikawa, Bo Zhang, Makoto Sugihara, Ken Mori, Atsushi Iwata, Akira Kawamura, Kazuyuki Shirai, Yoshinari Uehara, Masahiro Ogawa, Shin-Ichiro Miura, Keijiro Saku
• Journal: Journal of cardiology (J Cardiol) Vol. 65 Issue 2 Pg. 105-11 (Feb 2015) ISSN: 1876-4738 [Electronic] Netherlands
• PMID: 24997801 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014. Published by Elsevier Ltd.

Chemical References

• Cholesterol, HDL
• Cholesterol, LDL
• Glycated Hemoglobin A
• Lipids
• Triglycerides
• hemoglobin A1c protein, human

Topics

• Aged
• Cardiovascular Diseases (blood, etiology)
• Cholesterol, HDL (blood)
• Cholesterol, LDL (blood)
• Coronary Restenosis (prevention & control)
• Female
• Glycated Hemoglobin (analysis)
• Humans
• Japan
• Lipids (blood)
• Male
• Middle Aged
• Percutaneous Coronary Intervention (adverse effects)
• Registries
• Renal Dialysis (adverse effects)
• Triglycerides (blood)