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[Use of the antioxidant ubinon in the complex treatment of patients with ischemic heart disease].

Abstract
A new Soviet antioxidant drug, ubinon, has been used in 75 patients with coronary heart disease (CHD) of functional classes I-III, including 12 patients with ventricular extrasystoles. Treatment with placebo in 10 patients produced no improvement and had no effect on their stress tolerance. Ubinon, taken as 90 and 135 mg/day doses, was shown to produce clinical improvement and raise stress tolerance, mostly in first- and second-class cases. In coronary patients with ventricular extrasystoles, ubinon enhanced antiarrhythmic effect of mexitil. The use of ubinon was accompanied by a drop in blood oxidant activity and a rise in antioxidant activity, an increase in blood 6-keto-PGF1 alpha, a fall in TxB2 and a suppression of platelet activity. In addition, coronary patients with ventricular extrasystoles showed reduced cAMP and cGMP content and elevated cAMP/cGMP ratio.
AuthorsV A Dudaev, V V Borodkin, A Abbud, I V Diukov
JournalKardiologiia (Kardiologiia) Vol. 29 Issue 1 Pg. 48-52 (Jan 1989) ISSN: 0022-9040 [Print] Russia (Federation)
Vernacular TitlePrimenenie antioksidanta ubinona v kompleksnom lechenii bo'lnykh ishemicheskoĭ bolez'niu serdtsa.
PMID2499730 (Publication Type: Clinical Trial, Controlled Clinical Trial, English Abstract, Journal Article)
Chemical References
  • Antioxidants
  • Placebos
  • Nitroglycerin
Topics
  • Adult
  • Aged
  • Antioxidants (administration & dosage)
  • Clinical Trials as Topic
  • Coronary Disease (drug therapy, etiology, metabolism)
  • Drug Therapy, Combination
  • Humans
  • Lipid Peroxidation (drug effects)
  • Male
  • Middle Aged
  • Nitroglycerin (administration & dosage)
  • Placebos

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