Abstract | BACKGROUND: The Gram-negative pathogenic bacteria Klebsiella oxytoca and Klebsiella pneumoniae produce the extended spectrum β-lactamase (ESBL) and cephalosporinase enzymes and are the major causes of hospital acquired (HA) infections and epidemics in non-hygienic communities in the majority of developing countries. METHODS: RESULTS: Of 175 K. oxytoca isolates, 143 were ESBL positive and 117 were fluoroquinolone resistant. Of 270 K. pneumoniae isolates, 200 were ESBL positive and 195 were independently fluoroquinolone resistant. The HA samples yielded more isolates than the community acquired (CA) samples for each species. The K. oxytoca strains were resistant to cefepime, gatifloxacin, ciprofloxacin, ceftazidime, levofloxacin and imipenem, whereas the K. pneumoniae strains were highly resistant to ampicillin, norfloxacin, ciprofloxacin, gatifloxacin, ofloxacin, amoxyclav, ceftazidime, cefepime, cefixime, piperacillin and imipenem. The ESBL-producing and fluoroquinolone-resistant K. pneumoniae strains were more prevalent than the K. oxytoca strains in the HA/CA samples. The minimum inhibitory concentration values of the third-generation cephalosporins: cefotaxime and ceftazidime and the fluoroquinolones: ciprofloxacin and levofloxacin against both species of Klebsiella confirmed the resistance in the current/coveted treatment options. CONCLUSIONS:
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Authors | Shakti Rath, Rabindra N Padhy |
Journal | Journal of infection and public health
(J Infect Public Health)
2014 Nov-Dec
Vol. 7
Issue 6
Pg. 496-507
ISSN: 1876-035X [Electronic] England |
PMID | 24996691
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 King Saud Bin Abdulaziz University for Health Sciences. Published by Elsevier Ltd. All rights reserved. |
Chemical References |
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Topics |
- Anti-Bacterial Agents
(pharmacology)
- Drug Resistance, Multiple, Bacterial
- Female
- Hospitals, Teaching
- Humans
- India
(epidemiology)
- Klebsiella Infections
(epidemiology, microbiology)
- Klebsiella oxytoca
(drug effects, isolation & purification)
- Klebsiella pneumoniae
(drug effects, isolation & purification)
- Male
- Microbial Sensitivity Tests
- Prevalence
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