Abstract | PURPOSE: MATERIALS AND METHODS: Fifty-seven women with CNSP were randomized to strength + stretch or stretch alone exercise programs. Twenty-nine subjects underwent microdialysis procedure before and after 4-6 months of exercise. Twenty-four CON subjects underwent microdialysis procedure before and after 4-6 months without any intervention in between. Microdialysate samples were collected from the trapezius muscle and analyzed by mass spectrometry for PEA and SEA levels. RESULTS: PEA and SEA levels were significantly higher in CNSP patients compared with CON. PEA was significantly higher in CNSP than in CON after both training programs. SEA was significantly higher in CNSP than in CON after stretch alone but not after strength + stretch training. A significant positive correlation was found between changes in pain intensity and in SEA levels in the strength + stretch group, but not in the stretch alone group. CONCLUSION: Our results indicate that exercise interventions differentially affect the levels of the bioactive lipids PEA and SEA in the interstitium of the trapezius muscle in women with CNSP.
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Authors | Nazdar Ghafouri, Bijar Ghafouri, Christopher J Fowler, Britt Larsson, Maria V Turkina, Linn Karlsson, Björn Gerdle |
Journal | Pain medicine (Malden, Mass.)
(Pain Med)
Vol. 15
Issue 8
Pg. 1379-89
(Aug 2014)
ISSN: 1526-4637 [Electronic] England |
PMID | 24995488
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Wiley Periodicals, Inc. |
Chemical References |
- Amides
- Ethanolamines
- Palmitic Acids
- Stearic Acids
- stearoylethanolamide
- palmidrol
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Topics |
- Adult
- Amides
- Chronic Pain
(metabolism, rehabilitation)
- Ethanolamines
(analysis, metabolism)
- Exercise Therapy
(methods)
- Female
- Humans
- Mass Spectrometry
- Microdialysis
- Middle Aged
- Neck Pain
(metabolism, rehabilitation)
- Palmitic Acids
(analysis, metabolism)
- Shoulder Pain
(metabolism, rehabilitation)
- Stearic Acids
(analysis, metabolism)
- Superficial Back Muscles
(chemistry, metabolism)
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