Abstract | PURPOSE: METHODS: RESULTS: Treatment with preservative-free eye drops led to significant improvements in symptoms, tear film breakup time, Schirmer I score, and impression cytologic findings compared to treatment with preserved eye drops (P < 0.05) in patients with dry eye syndrome. There was a statistically significant decrease in the IL-1β, IL-6, IL-12, and TNF-α concentrations and a statistically significant increase in the catalase, peroxiredoxin 2, superoxide dismutase 2 (SOD 2), and thioredoxin mean fluorescence intensity (MFI) of tears in the preservative-free group at 1, 2, and 3 months compared to initial values, respectively (P < 0.05). CONCLUSIONS:
|
Authors | Donghyun Jee, Sang Hee Park, Man Soo Kim, Eun Chul Kim |
Journal | Investigative ophthalmology & visual science
(Invest Ophthalmol Vis Sci)
Vol. 55
Issue 8
Pg. 5081-9
(Jul 03 2014)
ISSN: 1552-5783 [Electronic] United States |
PMID | 24994869
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc. |
Chemical References |
- Antioxidants
- Cytokines
- Ophthalmic Solutions
- Preservatives, Pharmaceutical
|
Topics |
- Antioxidants
(metabolism)
- Cytokines
(metabolism)
- Dry Eye Syndromes
(complications, drug therapy, metabolism)
- Female
- Follow-Up Studies
- Humans
- Inflammation
(complications, drug therapy, metabolism)
- Male
- Middle Aged
- Ophthalmic Solutions
(administration & dosage)
- Preservatives, Pharmaceutical
(administration & dosage)
- Retrospective Studies
- Tears
(chemistry)
- Treatment Outcome
|