Abstract | BACKGROUND AND PURPOSE: MATERIALS AND METHODS: We retrospectively analyzed data from 129 consecutive, prospectively enrolled patients with stroke undergoing endovascular stroke therapy at a single tertiary care center between January 2006 and August 2013. Leukoaraiosis was assessed as supratentorial white matter hypoattenuation on admission head CT and graded as 0-2 (absent-to-moderate) versus 3-4 (severe) according to the van Swieten scale. We dichotomized the 90-day mRS into good (0-2 or return to baseline) versus poor (3-6) as the primary study outcome. Incremental multivariable logistic regression analyses were performed to identify independent predictors of a poor 90-day outcome. RESULTS: In all multivariable models, severe leukoaraiosis was independently (P < .05) associated with a poor outcome at 90 days (fully adjusted model: OR, 6.37; 95% CI, 1.83-12.18; P = .004). The independent association between leukoaraiosis and a poor outcome remained when the analysis was restricted to patients who were alive at discharge (n = 87, P < .05). Last, among patients who were alive at discharge, those with severe leukoaraiosis had significantly less frequent improvement on the mRS from discharge to 90 days compared with patients with absent-to-moderate leukoaraiosis (P = .034). CONCLUSIONS: The severity of pre-existing leukoaraiosis is independently associated with 90-day functional outcome in patients with stroke who underwent endovascular stroke therapy. These results highlight the need to further explore leukoaraiosis as a promising surrogate marker for poor outcome after endovascular stroke therapy to improve risk assessment, patient selection, and early prognostic accuracy.
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Authors | J Zhang, A S Puri, M A Khan, R P Goddeau Jr, N Henninger |
Journal | AJNR. American journal of neuroradiology
(AJNR Am J Neuroradiol)
2014 Nov-Dec
Vol. 35
Issue 11
Pg. 2070-5
ISSN: 1936-959X [Electronic] United States |
PMID | 24994827
(Publication Type: Journal Article)
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Copyright | © 2014 by American Journal of Neuroradiology. |
Topics |
- Aged
- Aged, 80 and over
- Embolization, Therapeutic
- Endovascular Procedures
- Female
- Humans
- Leukoaraiosis
(complications)
- Male
- Middle Aged
- Prognosis
- Recovery of Function
- Retrospective Studies
- Risk Assessment
- Stroke
(complications, diagnostic imaging, therapy)
- Tomography, X-Ray Computed
- Treatment Outcome
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