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TRAF4 participates in Wnt/β-catenin signaling in breast cancer by upregulating β-catenin and mediating its translocation to the nucleus.

Abstract
Tumor necrosis factor receptor-associated factor 4 (TRAF4) is upregulated in various subtypes of breast cancers and cell lines; however, the precise functions of TRAF4 are poorly understood. Our objective was to investigate its relationship with β-catenin. TRAF4 participates in several signaling pathways, such as NF-κB and JNK signaling pathways. In this study, we identified β-catenin as a TRAF4-binding protein, have shown that TRAF4 enhanced expression of β-catenin, and found that TRAF4 mediated the translocation of β-catenin from the cytoplasm to the nucleus, thereby facilitating activation of the Wnt signaling pathway in breast cancer.
AuthorsAilian Wang, Jian Wang, Huanyan Ren, Fan Yang, Lili Sun, Kexin Diao, Zhijuan Zhao, Min Song, Zeshi Cui, Enhua Wang, Minjie Wei, Xiaoyi Mi
JournalMolecular and cellular biochemistry (Mol Cell Biochem) Vol. 395 Issue 1-2 Pg. 211-9 (Oct 2014) ISSN: 1573-4919 [Electronic] Netherlands
PMID24990246 (Publication Type: Journal Article)
Chemical References
  • CTNNB1 protein, human
  • TNF Receptor-Associated Factor 4
  • TRAF4 protein, human
  • beta Catenin
Topics
  • Active Transport, Cell Nucleus
  • Breast Neoplasms (genetics, metabolism)
  • Cell Line, Tumor
  • Cell Nucleus (metabolism)
  • Female
  • Gene Expression Regulation, Neoplastic
  • Humans
  • MCF-7 Cells
  • TNF Receptor-Associated Factor 4 (genetics, metabolism)
  • Up-Regulation
  • Wnt Signaling Pathway
  • beta Catenin (metabolism)

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