Abstract |
Tumor necrosis factor receptor-associated factor 4 ( TRAF4) is upregulated in various subtypes of breast cancers and cell lines; however, the precise functions of TRAF4 are poorly understood. Our objective was to investigate its relationship with β- catenin. TRAF4 participates in several signaling pathways, such as NF-κB and JNK signaling pathways. In this study, we identified β- catenin as a TRAF4-binding protein, have shown that TRAF4 enhanced expression of β- catenin, and found that TRAF4 mediated the translocation of β- catenin from the cytoplasm to the nucleus, thereby facilitating activation of the Wnt signaling pathway in breast cancer.
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Authors | Ailian Wang, Jian Wang, Huanyan Ren, Fan Yang, Lili Sun, Kexin Diao, Zhijuan Zhao, Min Song, Zeshi Cui, Enhua Wang, Minjie Wei, Xiaoyi Mi |
Journal | Molecular and cellular biochemistry
(Mol Cell Biochem)
Vol. 395
Issue 1-2
Pg. 211-9
(Oct 2014)
ISSN: 1573-4919 [Electronic] Netherlands |
PMID | 24990246
(Publication Type: Journal Article)
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Chemical References |
- CTNNB1 protein, human
- TNF Receptor-Associated Factor 4
- TRAF4 protein, human
- beta Catenin
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Topics |
- Active Transport, Cell Nucleus
- Breast Neoplasms
(genetics, metabolism)
- Cell Line, Tumor
- Cell Nucleus
(metabolism)
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- MCF-7 Cells
- TNF Receptor-Associated Factor 4
(genetics, metabolism)
- Up-Regulation
- Wnt Signaling Pathway
- beta Catenin
(metabolism)
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