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Risk factors for eosinophilic esophagitis.

Abstract
Eosinophilic esophagitis (EoE) is a chronic antigen driven disease, whereby food and/or aeroallergens result in inflammation and luminal narrowing, and the clinical symptoms of dysphagia and food bolus obstruction events (FBOE). Established risk factors are male gender, Caucasian race and atopy. Increased risk amongst family members, and a single nucleotide polymorphism (SNP) in a gene coding thymic stromal lymphopoietin (TSLP) on the pseudoautosomal region of the X and Y chromosomes supports a genetic predisposition. Environmental factors including the timing and nature of food and aeroallergen exposure to the developing immune system may be important, whilst esophageal barrier function integrity and the influence of microbiota are worthy of future research.
AuthorsH Philpott, S Nandurkar, S G Royce, F Thien, P R Gibson
JournalClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (Clin Exp Allergy) Vol. 44 Issue 8 Pg. 1012-9 (Aug 2014) ISSN: 1365-2222 [Electronic] England
PMID24990069 (Publication Type: Journal Article, Review)
Copyright© 2014 John Wiley & Sons Ltd.
Chemical References
  • Allergens
Topics
  • Age Factors
  • Allergens (immunology)
  • Eosinophilic Esophagitis (epidemiology, etiology)
  • Female
  • Food (adverse effects)
  • Genetic Predisposition to Disease
  • Humans
  • Male
  • Microbiota
  • Risk Factors
  • Sex Factors

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