MMP-14 overexpression correlates with poor prognosis in non-small cell lung cancer.

Abstract

Matrix metalloproteinase-14 (MMP-14) has been demonstrated to play an important role in tumor progression. The aim of this study was to analyze the correlation between MMP-14 expression and clinicopathologic features and its prognostic significance in non-small cell lung cancer (NSCLC). Immunohistochemical staining for MMP-14 protein was performed in 104 patients with NSCLC. High levels of MMP-14 protein were positively correlated with the status of clinical stage (I-II vs. III-IV; P < 0.001), N classification (N0-N1 vs. N2-N3; P < 0.001), distant metastasis (no vs. yes; P = 0.014), and differentiated degree (high vs. low or undifferentiated; P = 0.001). The patients with higher MMP-14 expression of protein had shorter survival time than patients with low MMP-14 expression. Multivariate analysis indicated that the level of MMP-14 expression was an independent prognostic indicator (P < 0.001) for the survival of patients with NSCLC. In conclusion, MMP-14 is a potential unfavorable prognostic factor for patients with NSCLC.

• Authors: Yu-Zhou Wang, Kun-Peng Wu, Ai-Bing Wu, Zhi-Cheng Yang, Jin-Mei Li, Yan-Li Mo, Meng Xu, Bin Wu, Zhi-Xiong Yang
• Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol) Vol. 35 Issue 10 Pg. 9815-21 (Oct 2014) ISSN: 1423-0380 [Electronic] Netherlands
• PMID: 24986569 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• MMP14 protein, human
• Matrix Metalloproteinase 14

Topics

• Adult
• Aged
• Biomarkers, Tumor (analysis)
• Carcinoma, Non-Small-Cell Lung (metabolism, mortality, pathology)
• Female
• Humans
• Immunohistochemistry
• Kaplan-Meier Estimate
• Lung Neoplasms (metabolism, mortality, pathology)
• Male
• Matrix Metalloproteinase 14 (analysis, biosynthesis)
• Middle Aged
• Prognosis
• Proportional Hazards Models
• Up-Regulation