Abstract | BACKGROUND: METHODS: This was a retrospective cohort study of adult XDR-TB patients in KwaZulu-Natal, South Africa, treated with either a clofazimine- or non- clofazimine-containing XDR-TB treatment regimen. The primary outcome measure was TB culture conversion at 6 months. Survival analysis and multivariate logistic regression compared time to event in different strata and identified risk factors for TB culture conversion. RESULTS: Between August 2009 and July 2011, eligible XDR-TB patients (n = 85) were initiated on treatment for XDR-TB. Most patients (86%) were HIV-infected and receiving antiretroviral therapy (90%). Patients receiving a clofazimine-containing regimen (n = 50) had a higher percentage of culture conversion (40%) compared with patients (n = 35) receiving a non- clofazimine regimen (28.6%). On multivariate analysis, there was a 2-fold increase in TB culture conversion at 6 months (hazard rate ratio 2.54, 95% CI 0.99-6.52, P = 0.05) in the group receiving a clofazimine-containing regimen. Adverse effects due to clofazimine were minor and rarely life-threatening. CONCLUSIONS:
Clofazimine was associated with improved culture conversion in the treatment of XDR-TB/HIV. Adverse effects were minor and non-life-threatening. Based on these preliminary data, further study of clofazimine in XDR-TB/HIV treatment is warranted. Given the present low rates of culture conversion in XDR-TB treatment, we recommend empirical inclusion of clofazimine in treatment regimens for XDR-TB.
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Authors | N Padayatchi, M Gopal, R Naidoo, L Werner, K Naidoo, I Master, M R O'Donnell |
Journal | The Journal of antimicrobial chemotherapy
(J Antimicrob Chemother)
Vol. 69
Issue 11
Pg. 3103-7
(Nov 2014)
ISSN: 1460-2091 [Electronic] England |
PMID | 24986495
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | © The Author 2014. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: [email protected]. |
Chemical References |
- Antitubercular Agents
- Clofazimine
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Topics |
- Adult
- Antitubercular Agents
(therapeutic use)
- Clofazimine
(therapeutic use)
- Cohort Studies
- Coinfection
- Extensively Drug-Resistant Tuberculosis
(drug therapy, epidemiology)
- Female
- Follow-Up Studies
- HIV Infections
(drug therapy, epidemiology)
- Humans
- Male
- Retrospective Studies
- South Africa
(epidemiology)
- Treatment Outcome
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