APOE ε4 influences β-amyloid deposition in primary progressive aphasia and speech apraxia.

Abstract

BACKGROUND:

Apolipoprotein E ε4 (APOE ε4) is a risk factor for β-amyloid deposition in Alzheimer's disease dementia. Its influence on β-amyloid deposition in speech and language disorders, including primary progressive aphasia (PPA), is unclear.

METHODS:

One hundred thirty subjects with PPA or progressive speech apraxia underwent APOE genotyping and Pittsburgh compound B (PiB) PET scanning. The relationship between APOE ε4 and PiB status, as well as severity and regional distribution of PiB, was assessed.

RESULTS:

Forty-five subjects had an APOE ε4 allele and 60 subjects were PiB-positive. The odds ratio for a subject with APOE ε4 being PiB-positive compared with a subject without APOE ε4 being PiB-positive was 10.2 (95% confidence interval, 4.4-25.5; P < .0001). The APOE ε4 allele did not influence regional PiB distribution or severity.

CONCLUSION:

APOE ε4 increases the risk of β-amyloid deposition in PPA and progressive speech apraxia but does not influence regional β-amyloid distribution or severity.

• Authors: Keith A Josephs, Joseph R Duffy, Edythe A Strand, Mary M Machulda, Matthew L Senjem, Val J Lowe, Clifford R Jack Jr, Jennifer L Whitwell
• Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association (Alzheimers Dement) Vol. 10 Issue 6 Pg. 630-6 (Nov 2014) ISSN: 1552-5279 [Electronic] United States
• PMID: 24985533 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2014 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

Chemical References

• 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
• Amyloid beta-Peptides
• Aniline Compounds
• Apolipoprotein E4
• Thiazoles

Topics

• Aged
• Aged, 80 and over
• Amyloid beta-Peptides (metabolism)
• Aniline Compounds
• Aphasia, Primary Progressive (diagnostic imaging, genetics)
• Apolipoprotein E4 (genetics)
• Apraxias (diagnostic imaging, genetics)
• Brain Mapping
• Female
• Humans
• Male
• Middle Aged
• Positron-Emission Tomography
• Thiazoles