Pre-emptive peritonsillar dexamethasone vs. levobupivacaine infiltration for relief of post-adenotonsillectomy pain in children: a controlled clinical study.

Abstract

OBJECTIVES:

To investigate the effects of the pre-emptive local infiltration of dexamethasone vs. levobupivacaine on postoperative pain and morbidity in pediatric adenotonsillectomy patients.

METHODS:

A total of 60 patients (32 males and 28 females), aged 3-14 years, were included in this double-blind prospective randomized controlled clinical study from September of 2011 until May of 2012. Patients admitted for adenotonsillectomies after informed consent was obtained from the parents, and randomized into three groups receiving either dexamethasone sodium phosphate (Group 1, mean age 5.9 ± 1.6), levobupivacaine with epinephrine (Group 2, mean age 6.1 ± 2.6), or saline (Group 3, mean age 6.0 ± 3.4). Pain scores at the 1st, 4th, 8th, 12th, 16th, and 20th hours, and first, second, third and seventh days post-operatively were recorded by the parents using McGrath's face scale. The operation type, operation time and anesthesia time, the time of the first request for postoperative analgesia, and the total number of analgesic interventions were recorded.

RESULTS:

Pain scores were revealed in this order: Group 1 (steroid) < Group 2 (levobupivacaine) < Group 3 (saline) at all times (p = 0.000). The anesthesia times for Group 1 and Group 2 were different (steroid vs. levobupivacaine), and the time to first analgesic was longer in Groups 1 (steroid) and 2 (levobupivacaine) than in Group 3 (saline) (p < 0.000). The total number of analgesic interventions was lower in Group 1 (steroid) than in Group 2 (levobupivacaine) and Group 3 (saline) (steroid vs. saline, p = 0.000, and steroid vs. levobupivacaine, p < 0.05).

CONCLUSION:

Peritonsillar dexamethasone infiltration was more effective than both levobupivacaine and saline in reducing post-tonsillectomy pain. It was proven to be a safe and effective method.

• Authors: Dostbil Aysenur, Celik Mine, Yoruk Ozgur, Alıcı Hacı Ahmet, Erdem Ali Fuat, Ince Ilker, Ahiskalıoglu Ali
• Journal: International journal of pediatric otorhinolaryngology (Int J Pediatr Otorhinolaryngol) Vol. 78 Issue 9 Pg. 1467-71 (Sep 2014) ISSN: 1872-8464 [Electronic] Ireland
• PMID: 24984928 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Analgesics
• Anesthetics, Local
• Glucocorticoids
• dexamethasone 21-phosphate
• Dexamethasone
• Levobupivacaine
• Bupivacaine

Topics

• Adenoidectomy
• Adolescent
• Analgesics (therapeutic use)
• Anesthetics, Local (administration & dosage, therapeutic use)
• Bupivacaine (administration & dosage, analogs & derivatives, therapeutic use)
• Child
• Child, Preschool
• Dexamethasone (administration & dosage, analogs & derivatives, therapeutic use)
• Double-Blind Method
• Female
• Glucocorticoids (administration & dosage, therapeutic use)
• Humans
• Levobupivacaine
• Male
• Pain, Postoperative (drug therapy, etiology)
• Tonsillectomy