Abstract | BACKGROUND/AIM: PATIENTS AND METHODS: Medical records of recurrent TNBC patients receiving itraconazole with chemotherapy between 2008 and 2012 were retrospectively reviewed. RESULTS: Thirteen patients who progressed during prior chemotherapy (12 with visceral organ metastases) were enrolled. All patients had received docetaxel, carboplatin, and gemcitabine with itraconazole. Additionally, 3 patients with pleural effusion and 2 with inflammatory breast cancer received bevacizumab. No febrile neutropenia, platelet transfusion, or chemotherapy-related death was observed during treatment with itraconazole. The response rate, median progression-free survival, and median overall survival were 62% (95% confidence interval (CI): 35-88%), 10.8 months (95%CI: 7.6-15.3 months), and 20.4 months (95%CI: 13.1-41.4 months), respectively. CONCLUSION:
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Authors | Hiroshi Tsubamoto, Takashi Sonoda, Kayo Inoue |
Journal | Anticancer research
(Anticancer Res)
Vol. 34
Issue 7
Pg. 3839-44
(Jul 2014)
ISSN: 1791-7530 [Electronic] Greece |
PMID | 24982411
(Publication Type: Journal Article)
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Copyright | Copyright© 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved. |
Chemical References |
- Taxoids
- Deoxycytidine
- Docetaxel
- Itraconazole
- Carboplatin
- Gemcitabine
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Topics |
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Carboplatin
(administration & dosage)
- Deoxycytidine
(administration & dosage, analogs & derivatives)
- Docetaxel
- Female
- Humans
- Inflammatory Breast Neoplasms
(drug therapy)
- Itraconazole
(administration & dosage)
- Middle Aged
- Retrospective Studies
- Survival Rate
- Taxoids
(administration & dosage)
- Triple Negative Breast Neoplasms
(drug therapy)
- Gemcitabine
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