Abstract | INTRODUCTION: AREAS COVERED: EXPERT OPINION:
Solanezumab showed some beneficial cognitive effects in mildly affected AD patients and this subgroup of AD patients is currently being tested in another Phase III trial to this subgroup of AD patients to confirm previous encouraging observations. Two other monoclonal antibodies, gantenerumab, which preferentially binds to fibrillar Aβ, and crenezumab, which preferentially binds to soluble, oligomeric and fibrillar Aβ deposits, are being tested in secondary prevention trials in presymptomatic subjects with autosomal dominant AD mutations. Solanezumab is also being tested in a prevention study in asymptomatic older subjects, who have positive positron emission tomography scans for brain amyloid deposits. These ongoing secondary prevention trials will tell us if Aβ really plays a crucial role in the pathophysiology of AD.
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Authors | Francesco Panza, Vincenzo Solfrizzi, Bruno P Imbimbo, Giancarlo Logroscino |
Journal | Expert opinion on biological therapy
(Expert Opin Biol Ther)
Vol. 14
Issue 10
Pg. 1465-76
(Oct 2014)
ISSN: 1744-7682 [Electronic] England |
PMID | 24981190
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Amyloid beta-Peptides
- Antibodies, Monoclonal
- Antibodies, Monoclonal, Humanized
- gantenerumab
- solanezumab
- bapineuzumab
- crenezumab
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Topics |
- Alzheimer Disease
(drug therapy, immunology)
- Amyloid beta-Peptides
(immunology)
- Antibodies, Monoclonal
(therapeutic use)
- Antibodies, Monoclonal, Humanized
(therapeutic use)
- Humans
- Treatment Outcome
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