The protective effects of Schisandra chinensis fruit extract and its lignans against cardiovascular disease: a review of the molecular mechanisms.

Abstract

Schisandra chinensis fruit extract (SCE) has traditionally been used as an oriental medicine for the treatment of various human diseases, including cardiovascular disease. Advances in scientific knowledge and analytical technologies provide opportunities for translational research involving S. chinensis; such research may contribute to future drug discovery. To date, emerging experimental evidence supports the therapeutic effects of the SCE or its bioactive lignan ingredients in cardiovascular disease, unraveling the mechanistic basis for their pharmacological actions. In the present review, we highlight SCE and its lignans as promising resources for the development of safe, effective, and multi-targeted agents against cardiovascular disease. Moreover, we offer novel insight into future challenges and perspective on S. chinensis research to future clinical investigations and healthcare strategies.

• Authors: Jung Nyeo Chun, Minsoo Cho, Insuk So, Ju-Hong Jeon
• Journal: Fitoterapia (Fitoterapia) Vol. 97 Pg. 224-33 (Sep 2014) ISSN: 1873-6971 [Electronic] Netherlands
• PMID: 24976588 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2014 Elsevier B.V. All rights reserved.

Chemical References

• Lignans
• Plant Extracts

Topics

• Animals
• Apoptosis (drug effects)
• Cardiovascular Diseases (prevention & control)
• Fibrosis (drug therapy)
• Fruit
• Humans
• Inflammation (drug therapy)
• Lignans (pharmacology, therapeutic use)
• Oxidative Stress (drug effects)
• Phytotherapy
• Plant Extracts (pharmacology, therapeutic use)
• Schisandra
• Vasoconstriction (drug effects)