A unique perylene-based DNA intercalator: localization in cell nuclei and inhibition of cancer cells and tumors.

Abstract

To date, perylene derivatives have not been explored as DNA intercalator to inhibit cancer cells by intercalating into the base pairs of DNA. Herein, a water-soluble perylene bisimide (PBDI) that efficiently intercalates into the base pairs of DNA is synthesized. Excitingly, PBDI is superior to the commercial DNA intercalator, amonafide, for specific nuclear accumulation and effective suppression of cancer cells and tumors.

• Authors: Zejun Xu, Kunru Guo, Jieshi Yu, Haili Sun, Jun Tang, Jie Shen, Klaus Müllen, Wantai Yang, Meizhen Yin
• Journal: Small (Weinheim an der Bergstrasse, Germany) (Small) Vol. 10 Issue 20 Pg. 4087-92 (Oct 29 2014) ISSN: 1613-6829 [Electronic] Germany
• PMID: 24976526 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Intercalating Agents
• Perylene
• DNA

Topics

• Animals
• Cell Line, Tumor
• Cell Nucleus (metabolism)
• Cells, Cultured
• Circular Dichroism
• DNA (metabolism)
• Humans
• Intercalating Agents (metabolism)
• Molecular Structure
• Perylene (chemistry, metabolism)
• Spectrometry, Fluorescence