Correlation of midkine serum level with pro- and anti-inflamatory cytokines in multiple sclerosis.

Abstract

BACKGROUND:

Midkine (MK) is a heparin-binding growth factor with promoting effects in inflammatory responses through enhancing leukocytes migration.

OBJECTIVE:

To study the correlation between MK serum levels and concentration of inflammatory cytokines in Multiple Sclerosis (MS) patients.

METHODS:

We evaluated the MK level and its relationship with inflammatory cytokines (IL-17 and IL-23) and anti-inflammatory ones (IL-10 and TGF-β) in multiple sclerosis (MS) patients. The serum concentrations of MK and cytokines were assessed by ELISA in 32 MS patients in comparison with 32 healthy subjects.

RESULTS:

Our data showed that the MK concentration in MS patients is lower than healthy controls (341.15 ± 40.71 Pg/ml vs. 620.15 ± 98.61 Pg/ml, respectively, p=0.015). We also observed a significant decrease in IL-10, IL-23, and TGF-β cytokine levels in MS patients. There was a significant correlation between MK and IL-23 concentrations in our study (r = +0.829, p≤ 0.001).

CONCLUSION:

These results confirm a role for MK in inflammatory reactions in MS.

• Authors: Vahid Shaygannejad, Saeed Montazeri, Azam Jamshidian, Soheil Tahani, Marjan Gharagozloo, Fereshteh Ashtari, Sahar Vesal, Seyed Javad Hasheminia, Leila Dehghani
• Journal: Iranian journal of immunology : IJI (Iran J Immunol) Vol. 11 Issue 2 Pg. 134-8 (Jun 2014) ISSN: 1735-367X [Electronic] Iran
• PMID: 24975970 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cytokines
• Inflammation Mediators
• Midkine

Topics

• Adult
• Case-Control Studies
• Cytokines (blood)
• Female
• Humans
• Inflammation Mediators (blood)
• Male
• Midkine
• Multiple Sclerosis (blood, diagnosis, drug therapy)