Differences in coronary risk factors, procedural characteristics, mortality and stent thrombosis between two all-comers percutaneous coronary intervention registries from Europe and Japan: a patient-level data analysis of the Bern-Rotterdam and j-Cypher registries.

Abstract

AIMS:

The reported rate of stent thrombosis (ST) after drug-eluting stent (DES) implantation varies among registries. To investigate differences in baseline characteristics and clinical outcome in European and Japanese all-comers registries, we performed a pooled analysis of patient-level data.

METHODS AND RESULTS:

The j-Cypher registry (JC) is a multicentre observational study conducted in Japan, including 12,824 patients undergoing SES implantation. From the Bern-Rotterdam registry (BR) enrolled at two academic hospitals in Switzerland and the Netherlands, 3,823 patients with SES were included in the current analysis. Patients in BR were younger, more frequently smokers and presented more frequently with ST-elevation myocardial infarction (MI). Conversely, JC patients more frequently had diabetes and hypertension. At five years, the definite ST rate was significantly lower in JC than BR (JC 1.6% vs. BR 3.3%, p<0.001), while the unadjusted mortality tended to be lower in BR than in JC (BR 13.2% vs. JC 14.4%, log-rank p=0.052). After adjustment, the j-Cypher registry was associated with a significantly lower risk of all-cause mortality (HR 0.56, 95% CI: 0.49-0.64) as well as definite stent thrombosis (HR 0.46, 95% CI: 0.35-0.61).

CONCLUSIONS:

The baseline characteristics of the two large registries were different. After statistical adjustment, JC was associated with lower mortality and ST.

• Authors: Yoshinobu Onuma, Takeshi Kimura, Lorenz Räber, Michael Magro, Chrisafios Girasis, Ron van Domburg, Stephan Windecker, Kazuaki Mitsudo, Patrick W Serruys, Bern-Rotterdam and j-Cypher registries
• Journal: EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology (EuroIntervention) Vol. 11 Issue 5 Pg. 533-40 (Sep 2015) ISSN: 1969-6213 [Electronic] France
• PMID: 24974807 (Publication Type: Journal Article, Multicenter Study, Observational Study)

Topics

• Acute Coronary Syndrome (epidemiology, therapy)
• Age Factors
• Aged
• Coronary Thrombosis (epidemiology)
• Diabetes Mellitus (epidemiology)
• Drug-Eluting Stents
• Female
• Graft Occlusion, Vascular (epidemiology)
• Humans
• Hypertension (epidemiology)
• Japan
• Male
• Middle Aged
• Mortality
• Myocardial Infarction (epidemiology, therapy)
• Netherlands
• Percutaneous Coronary Intervention (statistics & numerical data)
• Prosthesis Failure
• Registries
• Risk Factors
• Smoking (epidemiology)
• Switzerland