Regulation of pumping function of the heart in developing body under changing regimens of motor activity.

Abstract

We analyzed parameters of the pumping function of the heart in rats subjected to enhanced motor activity after a preliminary 70-day hypokinesia under conditions of α- and β-adrenergic receptor stimulation with norepinephrine followed by blockade of β-adrenergic receptor with propranolol (obsidian) and α1-adrenergic receptors with doxazosin. After norepinephrine administration, the HR and cardiac output were higher in rats with enhanced physical activity after preliminary hypokinesia than in rats with low physical activity. After propranolol administration, stroke volume and cardiac output in 100-day-old rats with limited activity were lower, and HR higher was than in rats with enhanced physical activity after preliminary 70-day hypokinesia. After administration of doxazosin, rats with limited motor activity demonstrated more pronounced changes in HR than rats with enhanced physical activity after preliminary 70-day hypokinesia.

• Authors: E Z Vafina, R A Abzalov, N I Abzalov, A S Nikitin, A A Gulyakov
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 157 Issue 2 Pg. 177-9 (Jun 2014) ISSN: 1573-8221 [Electronic] United States
• PMID: 24970234 (Publication Type: Journal Article)

Chemical References

• Adrenergic alpha-1 Receptor Antagonists
• Adrenergic beta-Antagonists
• Propranolol
• Doxazosin

Topics

• Adrenergic alpha-1 Receptor Antagonists (therapeutic use)
• Adrenergic beta-Antagonists (therapeutic use)
• Animals
• Cardiac Output (drug effects)
• Doxazosin (therapeutic use)
• Heart (drug effects)
• Hypokinesia (drug therapy)
• Propranolol (therapeutic use)
• Rats
• Stroke Volume (drug effects)