In vitro and in vivo evaluation of antifungal agents.

Abstract

The evaluation of any antifungal agent involves the determination of its in vitro and in vivo activity against pathogenic and/or opportunistic fungi. The in vitro evaluation is followed by an in vivo evaluation in animal models, and clinical trials in humans. From the first report of the efficacy of the iodides for the treatment of sporotrichosis (1903) until the introduction of the imidazoles (azoles, 1960s), the number of antifungal agents available was very limited, including griseofulvin (1939), nystatin (1950), amphotericin B (1956), and flucytosine (1964). This paper briefly reviews the status of the antifungal agents currently used, and gives a more in depth evaluation of progress during recent years in the search for new antifungal drugs. Efforts to improve the efficacy of the current antifungal agents are also reviewed.

• Authors: A Espinel-Ingroff, S Shadomy
• Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology (Eur J Clin Microbiol Infect Dis) Vol. 8 Issue 4 Pg. 352-61 (Apr 1989) ISSN: 0934-9723 [Print] Germany
• PMID: 2497014 (Publication Type: Clinical Trial, Journal Article, Review)

Chemical References

• Antifungal Agents

Topics

• Animals
• Antifungal Agents (pharmacology, therapeutic use)
• Clinical Trials as Topic
• Drug Evaluation
• Drug Evaluation, Preclinical
• Fungi (drug effects)
• Humans
• Microbial Sensitivity Tests
• Mycoses (drug therapy)
• Opportunistic Infections (drug therapy)