Treatment of severe henoch-schonlein purpura nephritis with mycophenolate mofetil.

Abstract

Henoch-Schonlein purpura (HSP) is the most common childhood vasculitis. Renal involvement in HSP is one of the major causes of chronic renal failure in children. It is important to start effective and relatively safe medication to prevent end-stage renal disease (ESRD). Mycophenolate mofetil (MMF) appears to be a promising therapeutic agent in many autoimmune diseases such as lupus nephritis and vasculitis. Herein, we describe the treatment with MMF of three patients with HSP nephritis. In two cases with rapidly progressive glomerulonephritis without response to steroid, after treatment with MMF, significant improvement in kidney function and proteinuria were observed. In another patient with HSP nephritic-nephrotic syndrome who showed resistance to steroid, MMF offered a favorable effect. MMF seems to be a promising therapeutic agent in the treatment of the severe HSP nephritis.

• Authors: Ahmad Ali Nikibakhsh, Hashem Mahmoodzadeh, Mohamad Karamyyar, Sasan Hejazi, Mehran Noroozi, Ali Agayar Macooie
• Journal: Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia (Saudi J Kidney Dis Transpl) Vol. 25 Issue 4 Pg. 858-63 (Jul 2014) ISSN: 1319-2442 [Print] Saudi Arabia
• PMID: 24969202 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunosuppressive Agents
• Steroids
• Mycophenolic Acid

Topics

• Acute Kidney Injury (diagnosis, drug therapy, etiology)
• Biopsy
• Child
• Child, Preschool
• Drug Therapy, Combination
• Female
• Glomerulonephritis (diagnosis, drug therapy, etiology)
• Humans
• IgA Vasculitis (complications, diagnosis, drug therapy)
• Immunosuppressive Agents (therapeutic use)
• Male
• Mycophenolic Acid (analogs & derivatives, therapeutic use)
• Nephrotic Syndrome (diagnosis, drug therapy, etiology)
• Severity of Illness Index
• Steroids (therapeutic use)
• Treatment Outcome