Abstract | BACKGROUND: OBJECTIVE: We herein discuss the mechanism of action of amphiboles, focusing on the fibres identified in the study area. RESULTS: Human lung carcinoma cells have been exposed to two different materials: prismatic fluoro-edenite and fibres with fluoro-edenitic composition. Only in the second case, they exhibit features typical of transformed cells, such as multinucleation, prosurvival activity and pro-inflammatory cytokine release. Accordingly, in vivo studies demonstrated that the fibrous sample only could induce a mesotheliomatogenic effect. CONCLUSIONS:
|
Authors | Giulia Ballan, Antonella Del Brocco, Stefano Loizzo, Alessia Fabbri, Zaira Maroccia, Carla Fiorentini, Sara Travaglione |
Journal | Annali dell'Istituto superiore di sanita
(Ann Ist Super Sanita)
Vol. 50
Issue 2
Pg. 133-8
( 2014)
ISSN: 2384-8553 [Electronic] Italy |
PMID | 24968911
(Publication Type: Journal Article, Review)
|
Chemical References |
- Asbestos, Amphibole
- fluor-edenite
|
Topics |
- Animals
- Asbestos, Amphibole
(toxicity)
- Cell Line, Tumor
- Endemic Diseases
- Humans
- Inhalation Exposure
(adverse effects)
- Mesothelioma
(epidemiology, etiology, veterinary)
- Neoplasms
(epidemiology, etiology, veterinary)
- Particle Size
- Sicily
(epidemiology)
|