HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Efficacy of postoperative radiotherapy for high grade meningiomas.

Abstract
The necessity of postoperative radiotherapy (PORT) for meningiomas remains contentious. Here, the role of PORT in patients who underwent surgical resection for WHO grade II and III meningiomas was assessed. The record of 114 patients with WHO grade II (n = 72) and III (n = 42) meningiomas treated at Samsung Medical Center between March 1995 and April 2013 were reviewed and classified according to the extent of surgical resection and implementation of PORT. Median follow-up was 55.9 months. Simpson grade (SG) I, II, III, and IV resections were achieved in 29, 56, 9 and 20 patients, respectively. The 5-year local control (LC) and overall survival rate was 65.8 and 84.2 %, respectively. Thirty patients (26.3 %) developed local failure and five patients (4.4 %) developed distant metastases. The extent of surgical resection (SG I-II vs. III-IV) was influenced by tumor location (orbital and skull base lesions vs. others, p = 0.001) and the surgeons' experience (>10 operations, p = 0.044). Extent of surgical resection was also associated with local failure, overall progression, and overall survival (p = 0.001, p < 0.001, and p < 0.001, respectively). PORT improved LC in patients with incomplete surgical resection (SG III-IV, p = 0.049). Complete resection (SG I-II) is an important prognostic factor for LC and survival, and the extent of surgical resection (SG I-II vs. III-IV) is influenced by tumor location. PORT could improve the LC in WHO grade II-III meningioma patients who underwent incomplete surgical resection (SG III-IV).
AuthorsYunseon Choi, Do Hoon Lim, Kyungil Jo, Do-Hyun Nam, Ho Jun Seol, Jung-Il Lee
JournalJournal of neuro-oncology (J Neurooncol) Vol. 119 Issue 2 Pg. 405-12 (Sep 2014) ISSN: 1573-7373 [Electronic] United States
PMID24965339 (Publication Type: Journal Article)
Topics
  • Adult
  • Aged
  • Combined Modality Therapy (adverse effects)
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Meningioma (diagnosis, pathology, radiotherapy, surgery)
  • Middle Aged
  • Multivariate Analysis
  • Neoplasm Grading
  • Orbital Neoplasms (diagnosis, pathology, radiotherapy, surgery)
  • Prognosis
  • Skull Base Neoplasms (diagnosis, pathology, radiotherapy, surgery)
  • Survival Analysis
  • Treatment Outcome
  • Young Adult

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: