Abstract | OBJECTIVE: METHODS: RESULTS: Thirty two of 78 patients were male with median age of 60.4 years (range, 24-84). Cyst diameter ranged from 5 to 130 mm. For cyst fluid amylase, there was significant difference between PP and MCN (median, 30,034.50 vs. 4,723.50 U/L; p < 0.05) or IPMN (30,034.50 vs. 1,585.00; p = 0.001), but no difference between MCN and IPMN. For cyst fluid CEA, there was a significant difference between PP and MCN (median, 26.00 vs. 627.50 ng/mL; p < 0.001) or IPMN (26.00 vs. 356.50; p < 0.001). Median amylase and CEA values were significantly different between PP and mucinous neoplasms (MCN/IPMN) (p < 0.01 and p < 0.001). Optimal cutoff values of 6,800 U/mL for amylase and 50 ng/mL for CEA correlated with the crossover of the sensitivity and specificity curves for differentiating PP and mucinous neoplasms. The overall accuracies of cyst fluid amylase and CEA were 69 and 85%, respectively. CONCLUSIONS: Cyst fluid amylase analysis does not differentiate between MCN and IPMN. The combination of cyst fluid CEA and amylase value may increase the diagnostic accuracy for differentiating mucinous neoplasms from pseudocysts.
|
Authors | Hyoung-Chul Oh, Hyun Kang, William R Brugge |
Journal | Digestive diseases and sciences
(Dig Dis Sci)
Vol. 59
Issue 12
Pg. 3111-6
(Dec 2014)
ISSN: 1573-2568 [Electronic] United States |
PMID | 24965184
(Publication Type: Journal Article)
|
Chemical References |
- Biomarkers, Tumor
- Carcinoembryonic Antigen
- Amylases
|
Topics |
- Adult
- Aged
- Aged, 80 and over
- Amylases
(metabolism)
- Biomarkers, Tumor
(analysis)
- Carcinoembryonic Antigen
(metabolism)
- Cyst Fluid
(enzymology)
- Female
- Humans
- Male
- Middle Aged
- Pancreatic Cyst
(diagnosis, metabolism)
- Pancreatic Neoplasms
(diagnosis, metabolism)
- Young Adult
|