Effect of carbazochrome sodium sulfonate on refractory chronic prostatitis.

Abstract

OBJECTIVES:

To study the effect of carbazochrome sodium sulfonate, an agent that reduces capillary permeability, on refractory chronic prostatitis.

METHODS:

Patients with prostatitis refractory to at least 8 weeks of routine therapy and with urinalysis positive for microhematuria were considered for the present study. In addition to their prior therapy, the patients received carbazochrome at a dose of 30 mg three times a day. The severity of pain (score 0-10), daytime and night-time frequency, international prostate symptom score, global self-assessment, urine occult blood positivity, and adverse events were assessed after 4 and 8 weeks of treatment, and compared with baseline findings.

RESULTS:

A total of 50 patients (mean age 68.6 ± 8.5 years) were evaluable. The pain score decreased significantly from 3.2 ± 2.1 at baseline to 1.7 ± 1.4 after 4 weeks of treatment and to 1.1 ± 1.8 after 8 weeks. Daytime and night-time frequency, storage symptoms, post-micturition symptoms, and urine occult blood positivity also significantly improved. More than 36% of the patients gave a global self-assessment rating of "improved" or "better" after both 4 and 8 weeks of treatment. Mild adverse events occurred in three patients; one had nausea and two developed drug rash.

CONCLUSIONS:

Carbazochrome seems to effectively improve pain as well as storage and post-micturition symptoms in patients with refractory chronic prostatitis.

• Authors: Hitoshi Oh-oka, Tetsuo Yamada, Hiromitsu Noto, Tomokazu Umeyama, Katsumi Kadekawa, Katsuhiro Ashitomi, Saori Nishijima, Kimio Sugaya
• Journal: International journal of urology : official journal of the Japanese Urological Association (Int J Urol) Vol. 21 Issue 11 Pg. 1162-6 (Nov 2014) ISSN: 1442-2042 [Electronic] Australia
• PMID: 24964194 (Publication Type: Clinical Trial, Journal Article, Multicenter Study)
• Copyright: © 2014 The Japanese Urological Association.

Chemical References

• Hemostatics
• Adrenochrome
• carbazochrome

Topics

• Adrenochrome (analogs & derivatives, therapeutic use)
• Aged
• Chronic Disease
• Hemostatics (therapeutic use)
• Humans
• Male
• Middle Aged
• Prostatitis (drug therapy)
• Treatment Outcome