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Association between RANTES gene polymorphisms and asthma: a meta-analysis.

AbstractBACKGROUND:
A few recent studies have suggested that regulated on activation, normal T cell expressed and secreted (RANTES) polymorphisms (-403 G/A, -28C/G) are associated with asthma. However, there still existed studies which did not confirm these correlations.
OBJECTIVE:
The objective of this study was to evaluate the relationship of RANTES and asthma using a meta-analysis.
METHODS:
Pubmed, Embase, and Cochrane library databases were systemically searched. Data were extracted by two independent reviewers and pooled odds ratio (OR) with 95% confidence interval (CI) were calculated.
RESULTS:
Eighteen studies were enrolled, including a total of 2558 cases and 2630 controls of -403 G/A, as well as 3311 cases and 4031 controls of -28C/G in this meta-analysis. The overall ORs and 95% CIs of -403 G/A were 1.19, 1.06-1.33 (P<0.001) and 1.25, 1.03-1.51 (P = 0.933) in dominant and recessive models, respectively. The overall ORs and 95% CIs of -28G were 1.23, 1.09-1.39 (P = 0.221) and 1.76, 1.32-2.34 (P = 0.356) in dominant and recessive models, respectively. No publication bias among studies was showed.
CONCLUSIONS:
This meta-analysis showed that RANTES -403 G/A polymorphism was a risk factor for asthma, while -28C/G polymorphism were not associated with asthma.
AuthorsDan Wen, Xin Du, Shao-Ping Nie, Jian-Zeng Dong, Chang-Sheng Ma
JournalPloS one (PLoS One) Vol. 9 Issue 6 Pg. e90460 ( 2014) ISSN: 1932-6203 [Electronic] United States
PMID24963658 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)
Chemical References
  • Chemokine CCL5
Topics
  • Asthma (genetics)
  • Chemokine CCL5 (chemistry, genetics)
  • Genetic Association Studies
  • Genotype
  • Humans
  • Odds Ratio
  • Polymorphism, Genetic

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