Recent androgen receptor antagonists in prostate cancer.

Abstract

Androgen receptor has been shown to promote prostate cell growth and carcinogenesis of prostate cancer by up-regulating its target genes. Testosterone and dihydrotestosterone are two major hormones which bind to and activate androgen receptor. Targeting both the androgen receptor and the enzymes catalyzing the biosynthesis of testosterone and dihydrotestosterone has been shown to be clinically beneficial in the treatment of prostate cancer. Prostate cancer can become castration-resistant after long term treatment with chemo drugs, so efforts in finding compounds with improved efficiency to castration-resistant prostate cancer are urgently needed. In this review we summarized the studies on recent progress in the development of small molecular AR antagonists for the treatment of prostate cancer.

• Authors: Xufang Lu, Kang Dun, Yang Wang, Yong Yang, Qidong You, Zhiyu Li
• Journal: Mini reviews in medicinal chemistry (Mini Rev Med Chem) Vol. 14 Issue 8 Pg. 655-63 ( 2014) ISSN: 1875-5607 [Electronic] Netherlands
• PMID: 24958215 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Androgen Receptor Antagonists
• Small Molecule Libraries

Topics

• Androgen Receptor Antagonists (therapeutic use)
• Drug Delivery Systems (trends)
• Humans
• Male
• Prostatic Neoplasms (drug therapy)
• Small Molecule Libraries (chemical synthesis, therapeutic use)