Characteristics and functions of human cytomegalovirus UL128 gene/protein.

Abstract

Human cytomegalovirus (HCMV) ORF UL128 protein is highly conserved among viral field isolates and functions in two different molecular forms, monomeric UL128 protein and in a complex with glycoproteins gH, gL, UL130, and UL131A protein. Monomeric UL128 protein works as soluble chemokine analogue to attract peripheral blood mononuclear cells (PBMCs) and selectively induces expression of interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α) in PBMCs. The gH/gL/UL128/UL130/UL131A complex is indispensable for entry into both endothelial and epithelial cells. In conclusion, UL128 plays an important role in HCMV infection.

• Authors: R Tao, J Xu, H -H Gao, W -T Zhao, S -Q Shang
• Journal: Acta virologica (Acta Virol) Vol. 58 Issue 2 Pg. 103-7 ( 2014) ISSN: 0001-723X [Print] Slovakia
• PMID: 24957713 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Membrane Glycoproteins
• UL128 protein, human cytomegalovirus
• Viral Envelope Proteins

Topics

• Animals
• Cytomegalovirus (genetics, metabolism)
• Cytomegalovirus Infections (virology)
• Gene Expression Regulation, Viral
• Humans
• Membrane Glycoproteins (genetics, metabolism)
• Protein Binding
• Viral Envelope Proteins (genetics, metabolism)