Efficacy of cetuximab in metastatic colon cancer - case report.

Abstract

In recent years, targeted therapies have proved effective in the treatment of colon cancer, but even in these conditions,metastatic disease is generally considered incurable.Cetuximab is approved for the treatment of advanced colorectal cancer patients with KRAS wild-type, in order to increase survival and hinder progression of the disease. We report a case of a 55 year-old woman, diagnosed with stenosing sigmoid cancer and liver metastases, which underwent multimodal treatment: palliative surgery -Hartmann segmental colectomy, and adjuvant chemotherapy -second line monotherapy with cetuximab, according to standard protocols. After 6 months of XELOX chemotherapy,during which she showed progression of metastatic disease, she was switched to monotherapy with cetuximab, with favorable outcome. Comparing relevant literature, in which complete response to treatment with cetuximab is obtained in low percentages ( 3%) after 3 months of treatment with cetuximab the patient shows clinical and paraclinical complete response and increased quality of life. Proper selection of patients with metastatic colon cancer for treatment with anti-EGFR therapy may lead to prolonged survival and time to progression.

• Authors: V T Grigorean, A N Ciuhu, G Rahnea Nita, V Strambu, D N Straja, M Popescu, A M Sandu, R A Rahnea Nita
• Journal: Chirurgia (Bucharest, Romania : 1990) (Chirurgia (Bucur)) 2014 May-Jun Vol. 109 Issue 3 Pg. 383-9 ISSN: 1221-9118 [Print] Romania
• PMID: 24956345 (Publication Type: Case Reports, Journal Article)
• Copyright: Celsius.

Chemical References

• Antibodies, Monoclonal, Humanized
• Antineoplastic Agents
• Cetuximab

Topics

• Adenocarcinoma (drug therapy, secondary)
• Antibodies, Monoclonal, Humanized (therapeutic use)
• Antineoplastic Agents (therapeutic use)
• Cetuximab
• Colonic Neoplasms (drug therapy, pathology)
• Female
• Humans
• Liver Neoplasms (drug therapy, secondary)
• Middle Aged
• Treatment Outcome