In our previous study, the upregulation of
adipophilin in
lung adenocarcinoma were identified compared with normal lung tissues by quantitative proteomics. In this study, our aim was to verify the result from quantitative proteomics, further investigate the relationship between
adipophilin expression and clinicopathologic factors of
lung cancer patients. The expression levels of
adipophilin were examined in 10 pairs of
lung adenocarcinoma and normal lung tissues using western blotting and the expression and cellular distribution of
adipophilin were determined by IHC in 62
formalin-fixed and
paraffin embedded primary
lung cancer specimens.
Adipophilin expression was significantly higher in
lung adenocarcinoma specimens than in normal tissues and lung
squamous cell carcinomas (P<0.05). There were no significant difference of
adipophilin expression between lung
squamous cell carcinomas and normal lung tissues. The expression of
adipophilin in
lung cancer did not correlate with any clinicopathologic factors such as
lymph node metastasis, patients' age, gender,
tumor size, grade, and TNM stage. In Conclusion,
Adipophilin was upregulated in
lung adenocarcinoma, suggesting that
adipophilin play an important role in
tumorigenesis of
lung adenocarcinoma and may serve as a potential marker for
lung adenocarcinoma.