Pigmented Villonodular Synovitis (PVNS) is a relatively rare, benign proliferation lesion of the synovium of large joints. The etiology is varied and unclear. We had report a 79-year-old woman had PVNS after 14 years right hip
arthroplasty with
metal prosthesis. Here we report another 4 patients had PVNS after
arthroplasty. The second one had PVNS in the 2(th) year after hip
arthroplasty with
bone cement prosthesis. The specimen was brown and like usual PVNS in tissue. The third case had PVNS in the 8(th) after
arthroplasty with human bone
prosthesis because of the recurrence of PVNS. The proliferated synovium became black from brown. There was brown and many groups black pigment in the tissue. The fourth one had PVNS in the 4(th) year after
knee arthroplasty with
polyethylene prosthesis. The specimen was yellow. There was no pigment in the tissue but multinucleated giant cells with unstained
foreign body. The fifth patient had PVNS in the 10(th) month after the left hip
arthroplasty with
metal prosthesis. The macroscopy was yellow. There were
hemosiderin particles in the tissue but black
metal particles. This indicates that
arthroplasty with
prosthesis could cause some new disease or PVNS had new etiology with different pathological show.