Abstract | OBJECTIVES: METHODS: RESULTS: Areas under the curve on receiver operating characteristic analysis indicated the diagnostic sensitivity and specificity of hepcidin to be better than those of SI, TIBC, and TSAT. In ACD, hepcidin was correlated positively with IL-6 (r = 0.81, P < 0.01) and negatively with SI (r = -0.78, P < 0.01). In IDA, no significant relationship between IL-6 and hepcidin was found (r = -0.20, P = 0.17), but hepcidin decreased with decreasing quartiles of SI (r = 0.89, P < 0.01). SI was positively correlated with hemoglobin (r = 0.89, P < 0.01; r = 0.84, P < 0.01) in both groups. CONCLUSIONS:
Hepcidin is a promising serological marker for the differential diagnosis of tumor-related ACD and IDA, clarifying the pathogenesis of these anemias and guiding corrective treatment.
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Authors | Tingting Shu, Changwen Jing, Zhigang Lv, Yuchun Xie, Jiaren Xu, Jianzhong Wu |
Journal | European journal of haematology
(Eur J Haematol)
Vol. 94
Issue 1
Pg. 67-73
(Jan 2015)
ISSN: 1600-0609 [Electronic] England |
PMID | 24954786
(Publication Type: Journal Article)
|
Copyright | © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
Chemical References |
- Biomarkers
- Hepcidins
- Iron
|
Topics |
- Adult
- Aged
- Anemia, Iron-Deficiency
(blood, diagnosis, etiology)
- Biomarkers
(blood)
- Chronic Disease
- Diagnosis, Differential
- Erythrocyte Indices
- Female
- Hepcidins
(blood)
- Humans
- Iron
(metabolism)
- Male
- Middle Aged
- Neoplasms
(complications, diagnosis)
- Prospective Studies
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