HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Determination of β-N-oxalyl-L-α,β-diaminopropionic acid and homoarginine in Lathyrus sativus and Lathyrus cicera by capillary zone electrophoresis.

AbstractBACKGROUND:
Lathyrus species as legumes represent an alternative protein source for human and animal nutrition. Heavy consumption of these species can lead to lathyrism, caused by the non-protein amino acid β-N-oxalyl-l-α,β-diaminopropionic acid (β-ODAP). Currently, there is no well-defined level below which β-ODAP is considered non-toxic. In this work, the β-ODAP content was determined in L. sativus and L. cicera samples to assess their potential toxicity. Homoarginine is another non-protein amino acid found in Lathyrus spp. with interesting implications for human and animal nutrition.
RESULTS:
The level of β-ODAP found in these two species ranged from 0.79 to 5.05 mg g(-1). The homoarginine content of the samples ranged from 7.49 to 12.44 mg g(-1).
CONCLUSION:
This paper describes an accurate, fast and sensitive method of simultaneous detection and quantification of β-ODAP and homoarginine by capillary zone electrophoresis in L. cicera and L. sativus seeds. Moreover, several methods of extraction were compared to determine the highest performance.
AuthorsMara Sacristán, Alejandro Varela, Mercedes M Pedrosa, Carmen Burbano, Carmen Cuadrado, M Estrella Legaz, Mercedes Muzquiz
JournalJournal of the science of food and agriculture (J Sci Food Agric) Vol. 95 Issue 7 Pg. 1414-20 (May 2015) ISSN: 1097-0010 [Electronic] England
PMID24954190 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright© 2014 Society of Chemical Industry.
Chemical References
  • Dietary Proteins
  • beta-Alanine
  • Homoarginine
  • 2,3-diaminopropionic acid
Topics
  • Animals
  • Diet
  • Dietary Proteins
  • Electrophoresis, Capillary (methods)
  • Homoarginine (adverse effects, analysis)
  • Humans
  • Lathyrism (etiology)
  • Lathyrus (adverse effects, chemistry)
  • Seeds (chemistry)
  • beta-Alanine (adverse effects, analogs & derivatives, analysis)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: