Crosstalk between DNA repair and cancer stem cell (CSC) associated intracellular pathways.

Abstract

DNA damaging agents (ionizing radiation and chemotherapeutics) are considered as most effective in cancer treatment. However, there is a subpopulation of carcinoma cells within the tumour demonstrating resistance to DNA damaging treatment approaches. It is suggested that limited tumour response to this kind of therapy can be associated with specific molecular properties of carcinoma stem cells (CSCs) representing the most refractory cell subpopulation. This review article presents novel data about molecular features of CSCs underlying DNA damage response and related intracellular signalling.

• Authors: Sergej Skvortsov, Paul Debbage, Peter Lukas, Ira Skvortsova
• Journal: Seminars in cancer biology (Semin Cancer Biol) Vol. 31 Pg. 36-42 (Apr 2015) ISSN: 1096-3650 [Electronic] England
• PMID: 24954010 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2014 Elsevier Ltd. All rights reserved.

Chemical References

• Antineoplastic Agents
• APEX1 protein, human
• DNA-(Apurinic or Apyrimidinic Site) Lyase

Topics

• Antineoplastic Agents (therapeutic use)
• DNA Damage
• DNA Repair
• DNA-(Apurinic or Apyrimidinic Site) Lyase (genetics, metabolism)
• Gene Expression Regulation, Neoplastic (drug effects)
• Humans
• Models, Genetic
• Neoplasms (drug therapy, genetics, metabolism)
• Neoplastic Stem Cells (drug effects, metabolism, pathology)
• Signal Transduction (drug effects, genetics)