Effect of hepatitis B vaccination in patients with chronic hepatitis C.

Abstract

OBJECTIVE:

To assess the effects of hepatitis B vaccination on the antibody titer in patients with chronic hepatitis C and to compare it with response in normal healthy subjects.

STUDY DESIGN:

Interventional study.

PLACE AND DURATION OF STUDY:

Shifa International Hospital, Islamabad, Pakistan, from January 2007 to January 2012.

METHODOLOGY:

Hepatitis vaccination (Heberbiovac-HB 20) was given intramuscularly to the patients of chronic hepatitis C (HCV group) and normal healthy subjects (control group) at 0, 1 and 6 months intervals. Anti-HBs titer was determined after second and third injection to assess the antibody response.

RESULTS:

There were 46 patients in the HCV group and 45 patients in the control group. Mean age was 40.9 ± 9.8 years in the HCV group and 33.18 ± 8.35 years in the control group. Weight was 67.04 ± 13.5 kg in the HCV group and 71.78 ± 14.63 kg in the control group. Height was 162.45 ± 9.06 cm in the HCV group and 167.03 ± 7.83 cm in the control group. Anti-HBs antibody levels after the second injection were 253.89 ± 76.76 mlU/mL in the HCV group and 245.81 ± 72.65 mlU/mL in the control group (p=0.172). After third injection, the antibody levels were slightly higher in both groups.

CONCLUSION:

In patients with chronic hepatitis C and normal healthy subjects, Heberbiovac HB in standard dosage gave sero-protective levels in both groups and antibody titers were not significantly different in control and HCV group.

• Authors: Nasir Khokhar, Tariq Khan Niazi, Muhammad Omar Qureshi
• Journal: Journal of the College of Physicians and Surgeons--Pakistan : JCPSP (J Coll Physicians Surg Pak) Vol. 24 Issue 6 Pg. 392-5 (Jun 2014) ISSN: 1681-7168 [Electronic] Pakistan
• PMID: 24953911 (Publication Type: Journal Article)

Chemical References

• Hepatitis B Antibodies
• Hepatitis B Core Antigens
• Hepatitis B Vaccines
• Hepatitis C Antibodies
• Vaccines, DNA
• heberbiovac-HB

Topics

• Adolescent
• Adult
• Case-Control Studies
• Female
• Hepacivirus (immunology)
• Hepatitis B (prevention & control)
• Hepatitis B Antibodies (immunology)
• Hepatitis B Core Antigens (blood)
• Hepatitis B Vaccines (administration & dosage, adverse effects, immunology)
• Hepatitis C Antibodies (blood)
• Hepatitis C, Chronic (blood, immunology)
• Humans
• Immunization Schedule
• Injections, Intramuscular
• Male
• Middle Aged
• Pakistan
• Vaccination (methods)
• Vaccines, DNA (administration & dosage)