Abstract |
Eisenia bicyclis is edible brown algae recognized as a rich source of bioactive derivatives mainly phlorotannins reported for their anti-oxidant properties. Of all phlorotannins identified so far, dieckol has shown the most potent effect in anti-inflammatory, radical scavenging and neuroprotective functions. However, whether dieckol up-regulates hemeoxygenase 1 (HO-1) and this mediates its anti-inflammatory effect in murine macrophages remains poorly understood. Dieckol (12.5-50 μM) inhibited nitric oxide production and attenuated inducible nitric oxide synthase, phospho (p)-PI-3K, p-Akt, p-IKK-α/β, p-IκB-α and nuclear p-NF-κBp65 protein expressions, and NF-κB transcriptional activity in LPS (0.1 μg/ml) stimulated murine macrophages. On the other hand, dieckol up-regulated HO-1 which partly mediated its anti-inflammatory effect in murine macrophages. Thus, dieckol appeared to be a potential therapeutic agent against inflammation through HO-1 up-regulation.
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Authors | Taddesse Yayeh, Eun Ju Im, Tae-Hyung Kwon, Seong-Soo Roh, Suk Kim, Ji Hye Kim, Seung-Bok Hong, Jae Youl Cho, Nyun-Ho Park, Man Hee Rhee |
Journal | International immunopharmacology
(Int Immunopharmacol)
Vol. 22
Issue 1
Pg. 51-8
(Sep 2014)
ISSN: 1878-1705 [Electronic] Netherlands |
PMID | 24953853
(Publication Type: Journal Article)
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Copyright | Copyright © 2014 Elsevier B.V. All rights reserved. |
Chemical References |
- Anti-Inflammatory Agents
- Antioxidants
- Benzofurans
- Lipopolysaccharides
- NF-kappa B
- dieckol
- Nitric Oxide
- Heme Oxygenase-1
- Phosphatidylinositol 3-Kinases
- Oncogene Protein v-akt
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Topics |
- Animals
- Anti-Inflammatory Agents
(pharmacology)
- Antioxidants
(pharmacology)
- Benzofurans
(pharmacology)
- Cell Line
- Heme Oxygenase-1
(genetics, immunology, metabolism)
- Inflammation
(drug therapy)
- Lipopolysaccharides
(immunology)
- Macrophage Activation
(drug effects)
- Macrophages
(drug effects, immunology)
- Mice
- NF-kappa B
(metabolism)
- Nitric Oxide
(metabolism)
- Oncogene Protein v-akt
(metabolism)
- Phaeophyta
(immunology)
- Phosphatidylinositol 3-Kinases
(metabolism)
- Signal Transduction
(drug effects)
- Up-Regulation
(drug effects)
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