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Hemeoxygenase 1 partly mediates the anti-inflammatory effect of dieckol in lipopolysaccharide stimulated murine macrophages.

Abstract
Eisenia bicyclis is edible brown algae recognized as a rich source of bioactive derivatives mainly phlorotannins reported for their anti-oxidant properties. Of all phlorotannins identified so far, dieckol has shown the most potent effect in anti-inflammatory, radical scavenging and neuroprotective functions. However, whether dieckol up-regulates hemeoxygenase 1 (HO-1) and this mediates its anti-inflammatory effect in murine macrophages remains poorly understood. Dieckol (12.5-50 μM) inhibited nitric oxide production and attenuated inducible nitric oxide synthase, phospho (p)-PI-3K, p-Akt, p-IKK-α/β, p-IκB-α and nuclear p-NF-κBp65 protein expressions, and NF-κB transcriptional activity in LPS (0.1 μg/ml) stimulated murine macrophages. On the other hand, dieckol up-regulated HO-1 which partly mediated its anti-inflammatory effect in murine macrophages. Thus, dieckol appeared to be a potential therapeutic agent against inflammation through HO-1 up-regulation.
AuthorsTaddesse Yayeh, Eun Ju Im, Tae-Hyung Kwon, Seong-Soo Roh, Suk Kim, Ji Hye Kim, Seung-Bok Hong, Jae Youl Cho, Nyun-Ho Park, Man Hee Rhee
JournalInternational immunopharmacology (Int Immunopharmacol) Vol. 22 Issue 1 Pg. 51-8 (Sep 2014) ISSN: 1878-1705 [Electronic] Netherlands
PMID24953853 (Publication Type: Journal Article)
CopyrightCopyright © 2014 Elsevier B.V. All rights reserved.
Chemical References
  • Anti-Inflammatory Agents
  • Antioxidants
  • Benzofurans
  • Lipopolysaccharides
  • NF-kappa B
  • dieckol
  • Nitric Oxide
  • Heme Oxygenase-1
  • Phosphatidylinositol 3-Kinases
  • Oncogene Protein v-akt
Topics
  • Animals
  • Anti-Inflammatory Agents (pharmacology)
  • Antioxidants (pharmacology)
  • Benzofurans (pharmacology)
  • Cell Line
  • Heme Oxygenase-1 (genetics, immunology, metabolism)
  • Inflammation (drug therapy)
  • Lipopolysaccharides (immunology)
  • Macrophage Activation (drug effects)
  • Macrophages (drug effects, immunology)
  • Mice
  • NF-kappa B (metabolism)
  • Nitric Oxide (metabolism)
  • Oncogene Protein v-akt (metabolism)
  • Phaeophyta (immunology)
  • Phosphatidylinositol 3-Kinases (metabolism)
  • Signal Transduction (drug effects)
  • Up-Regulation (drug effects)

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