Abstract | OBJECTIVE: METHODS: A total of 99 surgically resected nodular HCCs with a maximum diameter of 3 cm or less were analysed. HCCs were macroscopically categorized as simple nodular (SN) and non-SN. CEUS findings were evaluated during the arterial phase (vascularity, level and shape of enhancement), portal phase (presence or absence of washout) and post-vascular phase (echo intensity and shape). RESULTS: Sixty-eight HCCs were categorized as SN and the remaining 31 were categorized as non-SN. For diagnosis of non-SN HCC, the areas under the receiver operating characteristic curve (A z) value for the shape of enhancement in the late arterial phase and the shape of the post-vascular image were 0.824 (95 % confidence interval [CI] 0.721-0.895) and 0.878 (95 % CI 0.788-0.933), respectively. The A z value for the combination of the shape of enhancement in the late arterial phase and the shape of the post-vascular image for the diagnosis of non-SN HCC was 0.907 (95 % CI 0.815-0.956), corresponding to a high diagnostic value. CONCLUSION: CEUS can provide high-quality imaging assessment for determining the macroscopic classification of small nodular HCCs. KEY POINTS: • Non-SN is one of the poor prognostic factors in patients with HCC • Assessment of macroscopic type provides valuable information for the management of HCC • CEUS can provide high-quality imaging assessment for macroscopic classification of HCC • For non-SN HCC diagnosed using CEUS, hepatectomy is preferred as curative treatment.
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Authors | Toshifumi Tada, Takashi Kumada, Hidenori Toyoda, Takanori Ito, Yasuhiro Sone, Yuji Kaneoka, Atsuyuki Maeda, Seiji Okuda, Katsuhiko Otobe, Kenichi Takahashi |
Journal | European radiology
(Eur Radiol)
Vol. 24
Issue 9
Pg. 2157-66
(Sep 2014)
ISSN: 1432-1084 [Electronic] Germany |
PMID | 24952601
(Publication Type: Journal Article)
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Chemical References |
- Fluorocarbons
- perfluorobutane
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Topics |
- Aged
- Carcinoma, Hepatocellular
(diagnostic imaging, pathology, surgery)
- Female
- Fluorocarbons
- Follow-Up Studies
- Hepatectomy
- Humans
- Image Enhancement
(methods)
- Liver
(diagnostic imaging, pathology, surgery)
- Liver Neoplasms
(diagnostic imaging, pathology, surgery)
- Male
- ROC Curve
- Retrospective Studies
- Ultrasonography
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