Abstract | INTRODUCTION: Intra-articular glucocorticoid treatment (IAGC) is widely used for symptom relief in arthritis. However, knowledge of factors predicting treatment outcome is limited. The aim of the present study was to identify response predictors of IAGC for knee synovitis in patients with rheumatoid arthritis (RA). METHODS: RESULTS: During the observation period, 48 knees relapsed (40%). Non-responders had more radiographic joint damage than responders (P = 0.002) and the pre-treatment vascular endothelial growth factor ( VEGF) level in synovial fluid was significantly higher in non-responders (P = 0.002). CONCLUSIONS: Joint destruction is associated with poor outcome of IAGC for knee synovitis in RA. In addition, higher levels of VEGF in synovial fluid are found in non-responders, suggesting that locally produced VEGF is a biomarker for recurrence of synovial hyperplasia and the risk for arthritis relapse.
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Authors | Tomas Weitoft, Johan Rönnelid, Ann Knight, Jörgen Lysholm, Tore Saxne, Anders Larsson |
Journal | Arthritis research & therapy
(Arthritis Res Ther)
Vol. 16
Issue 3
Pg. R129
(Jun 20 2014)
ISSN: 1478-6362 [Electronic] England |
PMID | 24950951
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents
- Biomarkers
- Glucocorticoids
- Vascular Endothelial Growth Factor A
- Triamcinolone Acetonide
- triamcinolone hexacetonide
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Topics |
- Adult
- Aged
- Anti-Inflammatory Agents
(administration & dosage, therapeutic use)
- Arthritis, Rheumatoid
(drug therapy, metabolism)
- Biomarkers
(blood, metabolism)
- Glucocorticoids
(administration & dosage, therapeutic use)
- Humans
- Injections, Intra-Articular
- Knee Joint
(drug effects, pathology)
- Logistic Models
- Middle Aged
- Multivariate Analysis
- Outcome Assessment, Health Care
(methods, statistics & numerical data)
- Predictive Value of Tests
- Prognosis
- Prospective Studies
- Recurrence
- Risk Factors
- Synovial Fluid
(metabolism)
- Synovitis
(drug therapy)
- Time Factors
- Triamcinolone Acetonide
(administration & dosage, analogs & derivatives, therapeutic use)
- Vascular Endothelial Growth Factor A
(blood, metabolism)
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