Current and emerging biomarkers of cell death in human disease.

Abstract

Cell death is a critical biological process, serving many important functions within multicellular organisms. Aberrations in cell death can contribute to the pathology of human diseases. Significant progress made in the research area enormously speeds up our understanding of the biochemical and molecular mechanisms of cell death. According to the distinct morphological and biochemical characteristics, cell death can be triggered by extrinsic or intrinsic apoptosis, regulated necrosis, autophagic cell death, and mitotic catastrophe. Nevertheless, the realization that all of these efforts seek to pursue an effective treatment and cure for the disease has spurred a significant interest in the development of promising biomarkers of cell death to early diagnose disease and accurately predict disease progression and outcome. In this review, we summarize recent knowledge about cell death, survey current and emerging biomarkers of cell death, and discuss the relationship with human diseases.

• Authors: Kongning Li, Deng Wu, Xi Chen, Ting Zhang, Lu Zhang, Ying Yi, Zhengqiang Miao, Nana Jin, Xiaoman Bi, Hongwei Wang, Jianzhen Xu, Dong Wang
• Journal: BioMed research international (Biomed Res Int) Vol. 2014 Pg. 690103 ( 2014) ISSN: 2314-6141 [Electronic] United States
• PMID: 24949464 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Biomarkers

Topics

• Apoptosis (genetics)
• Autophagy (genetics)
• Biomarkers
• Humans
• Mitosis
• Necrosis (genetics)