Abstract | BACKGROUND: METHODS: A total of 38 eyes of 20 patients with active RV associated to Behçet disease underwent UWF imaging with the Optos scanning laser ophthalmoscope, fundus autofluorescence, and/or fluorescein angiography. This study determined the UWF findings and percentage of patients in whom this imaging modality assisted in diagnosing the extent of vasculitis, planning treatment, and monitoring disease activity. RESULTS: Optos UWF imaging assisted in diagnosing and quantifying the extent of RV in 16 patients (80%), planning medical treatment or laser photocoagulation in 13 of 20 patients (65%), and enhanced disease monitoring in 11 of 20 patients (55%). UWF fluorescein angiography revealed vasculitis not clinically evident in 28 of 33 eyes (84.8%). Predominant angiographic findings were diffuse vascular leakage (75.7%), peripheral retinal nonperfusion (66.7%), optic disk leakage (63.6%), macular leakage (30.3%), and macular edema (27.3%). Eighteen patients (34 eyes) underwent UWF fundus autofluorescence, showing multiple hyperfluorescent spots in retinal periphery in 28 eyes (82.3%). CONCLUSION: Ultra-wide-field imaging is a valuable tool in the management of patients with RV associated to Behçet disease and can be used for the diagnosis, treatment, and follow-up. Additional studies, including longitudinal evaluations, are needed to elucidate whether these findings or the subsequent management alterations may improve patients' outcomes.
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Authors | Marina Mesquida, Victor Llorenç, José Ramón Fontenla, Manuel Javier Navarro, Alfredo Adán |
Journal | Retina (Philadelphia, Pa.)
(Retina)
Vol. 34
Issue 10
Pg. 2121-7
(Oct 2014)
ISSN: 1539-2864 [Electronic] United States |
PMID | 24946103
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Behcet Syndrome
(diagnosis, drug therapy)
- Capillary Permeability
- Female
- Fluorescein Angiography
- Humans
- Immunosuppressive Agents
(therapeutic use)
- Macular Edema
(diagnosis, drug therapy)
- Male
- Middle Aged
- Multimodal Imaging
(methods)
- Ophthalmoscopy
- Optical Imaging
- Retinal Neovascularization
(diagnosis, drug therapy)
- Retinal Vasculitis
(diagnosis, drug therapy)
- Retinal Vessels
(pathology)
- Retrospective Studies
- Young Adult
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