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Formulation of cidofovir improves the anti-papillomaviral activity of topical treatments in the CRPV/rabbit model.

Abstract
Current topical treatments for papillomas use ablative, cytotoxic and immunomodulating strategies and reagents. However, the effectiveness of topical treatments using different formulations has not been examined in preclinical models or clinical trials. The purpose of this study was to determine whether formulation of the small molecule acyclic nucleoside, cidofovir (CDV), could lead to improved therapeutic endpoints following topical treatment of papillomas using the cottontail rabbit papillomavirus (CRPV)/rabbit model. Different formulations with a set dose of 1% cidofovir were tested to establish comparative data. The results demonstrated that anti-papilloma treatments with topical CDV were greatly enhanced when formulated versus unformulated. Best results were obtained with CDV formulated in cremophor, then in Carbomer 940, and then in DMSO. Further studies indicated that effective formulations led to complete cures of papillomas at dilutions less than 0.3% CDV. These studies together with previous observations demonstrated that unformulated CDV under the same treatment regime required doses of 2% to achieve cures demonstrating that much less compound can be used when properly formulated.
AuthorsNeil D Christensen, Nancy M Cladel, Jiafen Hu, Karla K Balogh
JournalAntiviral research (Antiviral Res) Vol. 108 Pg. 148-55 (Aug 2014) ISSN: 1872-9096 [Electronic] Netherlands
PMID24946003 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
CopyrightCopyright © 2014 Elsevier B.V. All rights reserved.
Chemical References
  • Anti-Infective Agents, Local
  • Excipients
  • Organophosphonates
  • Cytosine
  • Cidofovir
Topics
  • Administration, Topical
  • Animals
  • Anti-Infective Agents, Local (chemistry, therapeutic use)
  • Chemistry, Pharmaceutical
  • Cidofovir
  • Cottontail rabbit papillomavirus (drug effects)
  • Cytosine (analogs & derivatives, chemistry, therapeutic use)
  • Excipients (chemistry)
  • Organophosphonates (chemistry, therapeutic use)
  • Papillomavirus Infections (veterinary, virology)
  • Rabbits
  • Treatment Outcome
  • Tumor Virus Infections (veterinary, virology)

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