Oral vitamin B12 treatment is effective for children with nutritional vitamin B12 deficiency.

Abstract

AIM:

Despite being one of common preventable deficiency disorders, vitamin B12 (vit-B12) deficiency can lead to serious health problems both in children and adult. The familiar treatment through parenteral route for vit-B12 deficiency frequently leads to poor adherence, and adequate response to treatment has lead to interest in oral supplementation. This study investigates the efficacy of oral vit-B12 treatment in children with nutritional vit-B12 deficiency.

METHODS:

Forty-seven children (from 1 month to 17 years) with vit-B12 levels below 200 pg/mL were allocated either of two study groups: Group 1 (1-20 months) and Group 2 (6-17 years) which were subdivided according to the duration of treatment (Group 1A&2A: 4 months; Group 1B&2B: 8 months of 1000 μg oral vit-B12, every day for a week, every other day for 2 weeks, 2 days a week for 2 weeks, then once a week).

RESULTS:

Vit-B12 levels among all groups were significantly restored following high oral vit-B12 doses (P = 0.013, P = 0.001), the regimen being more effective in Group1A and Group1B. Correlation analysis of serum vit-B12 levels and age at the end of treatment revealed a decreasing trend with the increasing patient age (corelation respectively -65.2%, P = 0.08; -35.4%; P = 0.25).

CONCLUSION:

Data from this study indicate that oral vit-B12 (1000 μg) for 4 months is effective, giving clinicians more choice, for treatment of children with nutritional vit-B12 deficiency. However, despite this high dose, lower levels were achieved in older children indicating the necessity of dosage adjustment in accordance with body weight.

• Authors: Aysenur Bahadir, Pınar Gökçe Reis, Erol Erduran
• Journal: Journal of paediatrics and child health (J Paediatr Child Health) Vol. 50 Issue 9 Pg. 721-5 (Sep 2014) ISSN: 1440-1754 [Electronic] Australia
• PMID: 24944005 (Publication Type: Journal Article)
• Copyright: © 2014 The Authors. Journal of Paediatrics and Child Health © 2014 Paediatrics and Child Health Division (Royal Australasian College of Physicians).

Chemical References

• Hemoglobins
• Vitamin B 12

Topics

• Administration, Oral
• Adolescent
• Child
• Child, Preschool
• Female
• Hemoglobins
• Humans
• Infant
• Male
• Prospective Studies
• Treatment Outcome
• Vitamin B 12 (blood, therapeutic use)
• Vitamin B 12 Deficiency (blood, drug therapy)