Abstract | OBJECTIVE: METHODS: We studied 5,205 men and women (mean age = 75 years) who were recruited into the PROspective Study of Pravastatin in the Elderly at Risk. All participants had pre-existing cardiovascular disease or risk factors thereof. Four domains of cognitive function were tested at baseline and repeated during a follow-up period of 3.2 years. RESULTS: Participants with higher NT-proBNP (≥450ng/l) had worse baseline cognitive function, including reaction time (mean difference high vs low group = 3.07 seconds, 95% confidence interval [CI] = 0.83 to 5.32), processing speed (-1.02 digits coded, 95% CI = -1.65 to -0.39), and immediate memory (-0.13 pictures remembered, 95% CI = -0.29 to 0.04). There was no significant difference in delayed memory (-0.14, 95% CI = -0.38 to 0.10) between the NT-proBNP groups. Participants with higher NT-proBNP had a steeper cognitive decline, including reaction time (mean annual change high vs low group = 0.60 seconds, 95% CI = 0.14 to 1.07), processing speed (-0.15 digits coded, 95% CI = -0.25 to -0.05), immediate memory (-0.05 pictures remembered, 95% CI = -0.09 to 0.00), and delayed memory (-0.05 pictures remembered, 95% CI = -0.11 to 0.01). Associations were independent of cardiovascular diseases and risks. INTERPRETATION:
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Authors | Liselotte W Wijsman, Behnam Sabayan, Peter van Vliet, Stella Trompet, Wouter de Ruijter, Rosalinde K E Poortvliet, Petra G van Peet, Jacobijn Gussekloo, J Wouter Jukema, David J Stott, Naveed Sattar, Ian Ford, Rudi G J Westendorp, Anton J M de Craen, Simon P Mooijaart |
Journal | Annals of neurology
(Ann Neurol)
Vol. 76
Issue 2
Pg. 213-22
(Aug 2014)
ISSN: 1531-8249 [Electronic] United States |
PMID | 24942833
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2014 American Neurological Association. |
Chemical References |
- Peptide Fragments
- pro-brain natriuretic peptide (1-76)
- Natriuretic Peptide, Brain
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Topics |
- Aged
- Aged, 80 and over
- Cardiovascular Diseases
(blood)
- Cognition Disorders
(blood)
- Female
- Humans
- Male
- Natriuretic Peptide, Brain
(blood)
- Peptide Fragments
(blood)
- Randomized Controlled Trials as Topic
- Risk
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