Evidence after imputation for a role of MICA variants in nonprogression and elite control of HIV type 1 infection.

Abstract

Past genome-wide association studies (GWAS) involving individuals with AIDS have mainly identified associations in the HLA region. Using the latest software, we imputed 7 million single-nucleotide polymorphisms (SNPs)/indels of the 1000 Genomes Project from the GWAS-determined genotypes of individuals in the Genomics of Resistance to Immunodeficiency Virus AIDS nonprogression cohort and compared them with those of control cohorts. The strongest signals were in MICA, the gene encoding major histocompatibility class I polypeptide-related sequence A (P = 3.31 × 10(-12)), with a particular exonic deletion (P = 1.59 × 10(-8)) in full linkage disequilibrium with the reference HCP5 rs2395029 SNP. Haplotype analysis also revealed an additive effect between HLA-C, HLA-B, and MICA variants. These data suggest a role for MICA in progression and elite control of human immunodeficiency virus type 1 infection.

• Authors: Sigrid Le Clerc, Olivier Delaneau, Cédric Coulonges, Jean-Louis Spadoni, Taoufik Labib, Vincent Laville, Damien Ulveling, Josselin Noirel, Matthieu Montes, François Schächter, Sophie Caillat-Zucman, Jean-François Zagury
• Journal: The Journal of infectious diseases (J Infect Dis) Vol. 210 Issue 12 Pg. 1946-50 (Dec 15 2014) ISSN: 1537-6613 [Electronic] United States
• PMID: 24939907 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: [email protected].

Chemical References

• HCP5 long noncoding RNA, human
• Histocompatibility Antigens Class I
• MHC class I-related chain A
• RNA, Long Noncoding
• RNA, Untranslated

Topics

• Adult
• Cohort Studies
• Disease Resistance
• Female
• Genetic Association Studies
• HIV Infections (immunology, virology)
• HIV-1 (immunology)
• Haplotypes
• Histocompatibility Antigens Class I (genetics)
• Humans
• Linkage Disequilibrium
• Major Histocompatibility Complex (genetics)
• Male
• Middle Aged
• Polymorphism, Single Nucleotide
• RNA, Long Noncoding
• RNA, Untranslated
• Young Adult