Abstract | OBJECTIVE: METHODS: Ten percent and 25% trichloroacetic acid were applied to warts weekly until all lesions cleared. Cryotherapy was performed by liquid nitrogen spray for 5-10 seconds for each lesion per week until the lesions cleared. The number of Verruca plana lesions and adverse effects were evaluated five times during the treatment (the initial visit, week 2, week 4, week 6, and week 8). RESULTS: The number of lesions decreased through week 8 for all three treatments, and the reductions in the mean numbers of lesions were statistically similar (p > 0.05). Those in the cryotherapy group exhibited more erythema, pain, erosions, bullae, and hyperpigmentation (p < 0.001, p < 0.001, p < 0.001, p < 0.05, and p = 0.001, respectively) than those in either TCA group. Itching was more common among those in the trichloroacetic acid groups than in the cryotherapy group (p < 0.05). Additionally, hyperpigmentation, erythema, pain, and itching were more frequent in the 25% trichloroacetic acid group than in the 10% trichloroacetic acid group (p < 0.001), (p < 0.05), (p < 0.05), (p < 0.05). CONCLUSION:
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Authors | Fatma Pelin Cengiz, Nazan Emiroglu |
Journal | Cutaneous and ocular toxicology
(Cutan Ocul Toxicol)
Vol. 34
Issue 2
Pg. 144-8
( 2015)
ISSN: 1556-9535 [Electronic] England |
PMID | 24938453
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Administration, Topical
- Adolescent
- Adult
- Child
- Child, Preschool
- Combined Modality Therapy
- Cryotherapy
- Dose-Response Relationship, Drug
- Female
- Humans
- Male
- Middle Aged
- Papillomavirus Infections
(drug therapy, therapy)
- Prospective Studies
- Trichloroacetic Acid
(administration & dosage, therapeutic use)
- Warts
(drug therapy, therapy)
- Young Adult
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