Abstract |
We observed the effects of a new thyrotropin-releasing hormone derivative, YM-14673 (N alpha-[[(S)-4-oxo-2-azetidinyl]carbonyl]-L-histidyl-L- prolinamide dihydrate), on behavioral changes in rats for 3 weeks after focal cerebral ischemia. Under halothane anesthesia, the left middle cerebral artery was occluded via a transretro-orbital approach. YM-14673 was administered just after the operation and once a day for 3 weeks. Neurologic deficits, including hemiplegia and abnormal posture, and disturbance of passive avoidance learning were present in solvent-treated control rats for the entire 3 weeks. YM-14673 at 0.1 or 0.3 mg/kg i.p. or 1 mg/kg p.o. significantly accelerated the recovery of neurologic deficits and ameliorated cognitive disturbance compared with the solvent-treated controls although the drug at 0.1 and 0.3 mg/kg i.p. did not influence the size of the ischemic infarct. YM-14673 mitigated the behavioral disturbances in this model of chronic focal cerebral ischemia. We also discuss the suitability of this model for the evaluation of drugs.
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Authors | M Yamamoto, A Tamura, T Kirino, M Shimizu, K Sano |
Journal | Stroke
(Stroke)
Vol. 20
Issue 3
Pg. 362-6
(Mar 1989)
ISSN: 0039-2499 [Print] United States |
PMID | 2493690
(Publication Type: Journal Article)
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Chemical References |
- Azetidines
- Azetines
- Dipeptides
- Thyrotropin-Releasing Hormone
- azetirelin
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Topics |
- Animals
- Avoidance Learning
(drug effects)
- Azetidines
(pharmacology)
- Azetines
(pharmacology)
- Behavior, Animal
(drug effects)
- Brain Ischemia
(complications, pathology, psychology)
- Cerebral Infarction
(pathology)
- Dipeptides
(pharmacology)
- Male
- Nervous System Diseases
(etiology, physiopathology)
- Rats
- Rats, Inbred Strains
- Reaction Time
- Thyrotropin-Releasing Hormone
(analogs & derivatives)
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