Serum levels of PYY(1-36) peptide in patients with schizophrenia on clozapine monotherapy.

Abstract

INTRODUCTION:

The present study was undertaken to determine if patients with schizophrenia on clozapine monotherapy have lower serum levels of peptide YY [PYY(1-36)], which is an endogenous inhibitor of food intake, comparing to healthy controls.

METHODS:

Data for 24 patients (mean age 38.8 years) with paranoid schizophrenia on clozapine monotherapy and 24 healthy subjects (gender- and age-matched; mean age 39.9 years) were analyzed.

RESULTS:

Fasting serum levels of PYY(1-36) were lower in the clozapine group (178.4±138.4 vs. 277.4±218.1 pg/mL, p=0.034). In the whole study sample PYY(1-36) levels were lower in subjects with body mass index≥25 kg/m(2) (p=0.03) and in subjects with abdominal obesity defined using International Diabetes Foundation criteria (p=0.04). There were no significant differences for metabolic syndrome, smoking, impaired fasting glucose, dyslipidemia, and homeostatic model assessment (HOMA) defined insulin resistance.

DISCUSSION:

RESULTS suggest that weight is asso-ciated with levels of PYY. Patients on clozapine had higher body mass index, but not fat mass index or body weight, therefore lower levels of PYY(1-36) in patients taking clozapine may result from clozapine-induced weight gain and central -obesity.

• Authors: A Wysokiński, M L Kowalski, I Kłoszewska
• Journal: Pharmacopsychiatry (Pharmacopsychiatry) Vol. 47 Issue 4-5 Pg. 169-73 (Jul 2014) ISSN: 1439-0795 [Electronic] Germany
• PMID: 24936806 (Publication Type: Clinical Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © Georg Thieme Verlag KG Stuttgart · New York.

Chemical References

• Antipsychotic Agents
• Peptide YY
• Clozapine

Topics

• Adult
• Antipsychotic Agents (pharmacology)
• Body Composition
• Body Mass Index
• Body Weight (drug effects)
• Clozapine (pharmacology)
• Electric Impedance
• Female
• Humans
• Male
• Metabolic Syndrome
• Middle Aged
• Peptide YY (blood, drug effects)
• Schizophrenia (drug therapy)
• Smoking